IS CHRONIC COCAINE ABUSE TOXIC TO THE HUMAN BRAIN?

长期滥用可卡因对人脑有毒吗?

基本信息

  • 批准号:
    3213834
  • 负责人:
  • 金额:
    $ 6.16万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1991
  • 资助国家:
    美国
  • 起止时间:
    1991-08-01 至 1994-07-31
  • 项目状态:
    已结题

项目摘要

Despite the explosive increase in cocaine abuse, little information is available with respect to the effects, in human brain, of long-term exposure to this drug. The major objective of our study is to conduct, for the first time, a systematic and comprehensive examination of the behaviour of the major neurotransmitter systems in autopsied brain of cocaine abusers. We propose to test the Specific Hypothesis that chronic cocaine abuse will be associated with long-lasting depletion in autopsied human brain in the markers for the monoamine neurotransmitters as assessed by HPLC, quantitative autoradiography, receptor binding, and photoaffinity labelling procedures. Autopsied cocaine-abused brain (n=10 per year for the next three years) will be carefully selected from over 250 possible autopsies at one Canadian (Toronto) and two U.S. (Minneapolis; Bronx, N.Y.) centers. The obtained neurochemical data will be compared with biochemical findings obtained in two drug (chronic heroin; alcohol) and one non-neurological group. All of the applicants have demonstrated expertise in the relevant human brain dissection, neurochemical, and neuropathological components of this investigation. Much effort is now being directed to experimental animal studies designed to understand the biochemical basis of cocaine addiction and the long-term changes in brain following chronic cocaine abuse. We argue that such studies should more appropriately be conducted in the human brain. We suggest that the results of our intensive study will provide, for the first time, baseline information with respect to the potential long-term pharmacologic/neurotoxicological efforts of cocaine as well as a springboard for formulating new treatment strategies for the human cocaine abuser.
尽管可卡因滥用呈爆炸式增长,但相关信息却很少

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

STEPHEN John KISH其他文献

STEPHEN John KISH的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('STEPHEN John KISH', 18)}}的其他基金

PET IMAGING STUDY OF BRAIN VMAT2 IN HUMAN METHAMPHETAMINE USERS
人类冰毒使用者大脑 VMAT2 的 PET 成像研究
  • 批准号:
    8428573
  • 财政年份:
    2010
  • 资助金额:
    $ 6.16万
  • 项目类别:
PET IMAGING STUDY OF BRAIN VMAT2 IN HUMAN METHAMPHETAMINE USERS
人类冰毒使用者大脑 VMAT2 的 PET 成像研究
  • 批准号:
    8044827
  • 财政年份:
    2010
  • 资助金额:
    $ 6.16万
  • 项目类别:
PET IMAGING STUDY OF BRAIN VMAT2 IN HUMAN METHAMPHETAMINE USERS
人类冰毒使用者大脑 VMAT2 的 PET 成像研究
  • 批准号:
    8216461
  • 财政年份:
    2010
  • 资助金额:
    $ 6.16万
  • 项目类别:
BRAIN SEROTONIN TRANSPORTER IN ECSTASY AND MDA USERS
摇头丸和丙二醛使用者的大脑血清素转运蛋白
  • 批准号:
    6924484
  • 财政年份:
    2005
  • 资助金额:
    $ 6.16万
  • 项目类别:
BRAIN SEROTONIN TRANSPORTER IN ECSTASY AND MDA USERS
摇头丸和丙二醛使用者的大脑血清素转运蛋白
  • 批准号:
    7216930
  • 财政年份:
    2005
  • 资助金额:
    $ 6.16万
  • 项目类别:
BRAIN SEROTONIN TRANSPORTER IN ECSTASY AND MDA USERS
摇头丸和丙二醛使用者的大脑血清素转运蛋白
  • 批准号:
    7060343
  • 财政年份:
    2005
  • 资助金额:
    $ 6.16万
  • 项目类别:
CHRONIC COCAINE AND HUMAN BRAIN DOPAMINE
慢性可卡因和人脑多巴胺
  • 批准号:
    2119461
  • 财政年份:
    1991
  • 资助金额:
    $ 6.16万
  • 项目类别:
CHRONIC COCAINE AND HUMAN BRAIN DOPAMINE
慢性可卡因和人脑多巴胺
  • 批准号:
    2119462
  • 财政年份:
    1991
  • 资助金额:
    $ 6.16万
  • 项目类别:
IS CHRONIC COCAINE ABUSE TOXIC TO THE HUMAN BRAIN?
长期滥用可卡因对人脑有毒吗?
  • 批准号:
    3213833
  • 财政年份:
    1991
  • 资助金额:
    $ 6.16万
  • 项目类别:
BRAIN NEUROCHEMISTRY OF HUMAN METHAMPHETAMINE USERS
人类甲基苯丙胺使用者的大脑神经化学
  • 批准号:
    2897834
  • 财政年份:
    1991
  • 资助金额:
    $ 6.16万
  • 项目类别:

相似海外基金

Development of Affinity Labeling Approaches for Protein Identification
蛋白质鉴定亲和标记方法的开发
  • 批准号:
    554025-2020
  • 财政年份:
    2020
  • 资助金额:
    $ 6.16万
  • 项目类别:
    University Undergraduate Student Research Awards
Design of a novel affinity labeling probe exhibiting fluorescence and luminescence
一种新型亲和标记探针的设计,具有荧光和发光功能
  • 批准号:
    16K17930
  • 财政年份:
    2016
  • 资助金额:
    $ 6.16万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Affinity Labeling the Dopamine Transporter Active Site
多巴胺转运蛋白活性位点的亲和标记
  • 批准号:
    6731145
  • 财政年份:
    2003
  • 资助金额:
    $ 6.16万
  • 项目类别:
Affinity Labeling the Dopamine Transporter Active Site
多巴胺转运蛋白活性位点的亲和标记
  • 批准号:
    6868946
  • 财政年份:
    2003
  • 资助金额:
    $ 6.16万
  • 项目类别:
Affinity Labeling the Dopamine Transporter Active Site
多巴胺转运蛋白活性位点的亲和标记
  • 批准号:
    6579786
  • 财政年份:
    2003
  • 资助金额:
    $ 6.16万
  • 项目类别:
SGER: X-ray Crystallographic and Affinity Labeling Analysis of the Structure of Rat Epididymal N-Acetyl-B-D-hexosaminidase: Insight into the Catalytic Mechanism
SGER:大鼠附睾 N-乙酰基-B-D-氨基己糖苷酶结构的 X 射线晶体学和亲和标记分析:深入了解催化机制
  • 批准号:
    9804595
  • 财政年份:
    1998
  • 资助金额:
    $ 6.16万
  • 项目类别:
    Standard Grant
Affinity Labeling of Nucleotide Sites in Proteins
蛋白质中核苷酸位点的亲和标记
  • 批准号:
    9728202
  • 财政年份:
    1998
  • 资助金额:
    $ 6.16万
  • 项目类别:
    Continuing Grant
AFFINITY LABELING OF GLUTATHIONE S TRANSFERASES
谷胱甘肽 S 转移酶的亲和标记
  • 批准号:
    2654163
  • 财政年份:
    1996
  • 资助金额:
    $ 6.16万
  • 项目类别:
AFFINITY LABELING OF GLUTATHIONE S TRANSFERASES
谷胱甘肽 S 转移酶的亲和标记
  • 批准号:
    2871848
  • 财政年份:
    1996
  • 资助金额:
    $ 6.16万
  • 项目类别:
AFFINITY LABELING OF GLUTATHIONE S TRANSFERASES
谷胱甘肽 S 转移酶的亲和标记
  • 批准号:
    2109965
  • 财政年份:
    1996
  • 资助金额:
    $ 6.16万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了