DOPAMINE INVOLVEMENT IN OPIATE & STIMULANT DRUG REIN-

阿片类药物中多巴胺的参与

• 批准号: 3211013
• 负责人: AARON ETTENBERG
• 金额: $ 6.5万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-03-01 至 1991-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3211013
• 关键词: amphetamines; behavioral extinction; central nervous system stimulants; cocaine; dopamine receptor; heroin; laboratory rat; morphine; narcotics; operant conditionings; opiate alkaloid; psychological reinforcement; psychopharmacology; reinforcer

Studies of food, water and brain-stimulation rewards have provided evidence that central dopaminergic (DA) substrates represent an important link in the neurobiology of positive reinforcement. Since abused drugs are presumed to act via a central activation of the brain's natural reward mechanism(s) it has been suggested that these DA pathways also mediate the reinforcing properties of self-administered drugs. Controversy exists, however, over whether or not such DA systems underlie the reward produced by all positive reinforcers or whether various independent systems exist in parallel within the CNS. The proposed research was devised to test the hypothesis that central DA neurons mediate the reinforcing properties of two major classes of abused drugs - the psychomotor stimulants (amphetamine, cocaine), and the opiate agonists (morphine and heroin). the effects of peripheral and central DA receptor antagonists on drug reward shall be examined in two novel behavioral paradigms: a Partial Reinforcement Extinction Test and an Incentive Motivation test. Both tests have the important advantage of assessing reward changes in animals that are no longer drugged at the time of testing. The proposed research should a) provide information relevant to our understanding of human stimulant and opiate drug abuse; and b) help elucidate the role of central DA neurons in the neural basis of drug reward.

对食物、水和大脑刺激奖励的研究 提供证据表明，中枢多巴胺能（DA）底物 代表了神经生物学中的一个重要环节， 加固. 由于滥用药物被认为是通过 大脑自然奖赏机制的中枢激活， 已经表明，这些DA途径也介导了 加强自我给药的特性。 争议 然而，存在这样的DA系统是否 所有正向行为产生的奖励， 独立的系统在CNS内并行存在。 的 一项拟议的研究旨在验证这一假设， DA神经元介导两种主要的增强特性， 滥用药物类别-精神兴奋剂 （安非他明，可卡因）和阿片激动剂（吗啡和 海洛因）。 外周和中枢DA受体的作用 拮抗剂对药物奖励应审查在两个新的 行为范式：部分强化消退测试 和激励动机测试 这两项测试都具有重要的 评估动物奖励变化的优势， 在测试时被麻醉的时间更长。 拟议研究 a）提供与我们理解有关的信息， 人类兴奋剂和阿片类药物滥用;和B）帮助阐明 中枢DA神经元在药物奖赏的神经基础中的作用。