MATERNAL CRACK USE: PERINATAL AND INFANCY EFFECTS

产妇快克使用：围产期和婴儿期的影响

• 批准号: 3212733
• 负责人: TOVE S. ROSEN
• 金额: $ 64.68万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 1996-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3212733
• 关键词: behavior test; child physical development; child psychology; crack cocaine; developmental neurobiology; drug abuse; embryo /fetus toxicology; female; infant human (0-1 year); longitudinal human study; mother child interaction; neurologic manifestations; neuropsychological tests; perinatal; pregnancy; pregnancy disorder; preschool child (1-5); questionnaires; ultrasonography; urinalysis

During the past few years there has been a tremendous increase in the abuse of crack in the pregnant population. In addition to the crack thee is a 30-35% abuse of other illicit drugs. There is a growing body of data on the perinatal effects of cocaine but very little information exists on the effects of crack. The overall purpose of the proposal is to investigate the effects of prenatal crack abuse on pregnancy and the early somatic and neurobehavioral development of the infant and young child. A total of 426 pregnant women will be enrolled in the study: 65% with a history of crack abuse; and 35% will be drug-free. Three time periods will be covered: gestation, neonatal, and infancy to 2 years. During pregnancy data will be collected on the use of crack including number, route, frequency. Use of other drugs of abuse will be noted. this will be done using drug intake questionnaires and urinary drug screens at frequent intervals. Data on past and present medical and obstetrical information as to infections, obstetrical complications, course of labor and delivery, nutrition and weight gain, fetal well being using fetal heart rate monitoring and ultrasonography will be collected. The neonate will have a physical and neurological exam. USG of the head to R/O congenital anomalies, and a cocaine intoxication symptom score. The Brazelton Neurobehavioral Assessment will be administered to evaluate early responsiveness. Charts will be reviewed for pertinent data. All infants will be enrolled in follow-up. The Infant Health Assessment Program (IHAP) was recently established in NYC with a mandate to track and ensure provision of comprehensive care to high risk infants. We will collaborate with the IHAP to ensure attendance at the follow-up clinic. The children will be seen at 6,12,18, and 24 months. To determine abnormalities growth para-meters, physical and neurological evaluations will be performed at each visit. Standard measures of cognitive and perceptual development will be administered to determine developmental and behavioral difficulties. To determine any deficits in communication and social skills standard measures and mother-infant interaction will be used. Maternal demographic and psychosocial data will be collected pre-and postnatally. The effects of crack use, maternal psychosocial functioning, prenatal and neonatal course, and mother infant interaction will be examined on the somatic and neurodevelopmental outcome of the infants. This information will provide a basis for recommendations for health care and intervention programs to minimize the risk for neurobehavioral and developmental problems.

在过去的几年里，虐待儿童的现象急剧增加， 怀孕人群中的可卡因含量 除了裂缝你是一个 30%-35%滥用其他非法药物。 越来越多的数据表明 可卡因对围产期的影响，但关于 裂纹的影响。 该提案的总体目的是调查 产前滥用快克对怀孕和早期体细胞和 婴儿和幼儿的神经行为发育。 共有426 孕妇将被纳入研究：65%有吸毒史 滥用; 35%将是无毒品。 将涵盖三个时间段： 妊娠期、新生儿和婴儿期至2岁。 妊娠期间的数据将 收集关于使用破解的信息，包括数量、路线、频率。 使用 其他滥用药物亦会记录在案。 这将通过药物摄入来完成 问卷调查和尿液药物筛查。 数据 关于感染的过去和现在的医疗和产科信息， 产科并发症、产程和分娩、营养和 体重增加，使用胎心率监测胎儿健康， 将收集超声检查结果。 新生儿将有一个物理和 神经系统检查。头部USG到R/O先天性异常，以及 可卡因中毒症状评分 Brazelton神经行为 将进行评估，以评价早期反应。 图表 将审查相关数据。 所有婴儿都将参加 随访 婴儿健康评估计划（IHAP）最近在纽约成立 其任务是跟踪和确保向高 风险婴儿 我们将与IHAP合作，以确保出席 后续诊所。 孩子们将在6个月、12个月、18个月和24个月时被观察。 以确定异常生长参数，身体和神经 将在每次访视时进行评价。 标准措施 认知和知觉发展将被管理，以确定 发展和行为困难。 为了确定任何赤字， 沟通和社会技能标准措施和母婴 互动将被使用。 产妇人口统计和心理社会数据将 在出生前和出生后收集。 使用快克的影响，母亲 社会心理功能、产前和新生儿病程以及母婴 交互作用将被检查的躯体和神经发育的结果 的婴儿。 这些信息将为建议提供依据 医疗保健和干预计划，以尽量减少风险， 神经行为和发育问题。