LONGITUDINAL STUDY OF THE IV-AIDS EPIDEMIC

回答关于IV-AIDS的许多最关键的问题 流行病需要长期的数据。因此，本提案寻求 资助开展一项非临床艾滋病毒感染的纵向研究 614个静脉注射吸毒者样本。他们是从街上通过外展招募的 在之前的一项研究中，三个小城市的角落。三次 在一年的时间里，先前的研究详细地采访了静脉注射吸毒者 关于性别和针头的使用，受试者每次都要接受测试 爱滋病毒。一半的受试者接受了社区范围的外展。 预防艾滋病传播的干预措施。利用这一点- 年数据库和继续访问样本，该提案旨在 通过每年进行四次以上的研究，进行为期五年的纵向研究 后续面谈和艾滋病毒检测。目前的工作人员已经实现了 在上一波采访中，这些受试者的随访率很高， 项目文件中包含大量关于 研究对象。因此，这项研究预计将完成以下后续行动 每年90%的受试者，并将使用新的分析技术 根据自然减员进行调整。生成的数据将用于评估 艾滋病预防的长效性，决定着艾滋病的稳定性 危险行为的变化，描述了随着时间的推移血清转换率， 并前瞻性研究感染率趋于平稳的趋势。 该项目还将使用计算机化的地图来分析 居住地和艾滋病毒状况，以便从地理上跟踪疫情 随着时间的推移，并将审查艾滋病对无家可归者和非流浪者的影响 随着时间推移无家可归的静脉注射吸毒者。

Answering many of the most critical questions concerning the IV-AIDS epidemic requires long-term data. Accordingly, this proposal seeks funds to conduct a longitudinal study of HIV infection in a non-clinical sample of 614 IVDUs. They were recruited by outreach from the street corners of three small cities during a previous study. Three times during a year, the previous study interviewed the IVDUs in detail regarding sex and needle use, and the subjects were tested each time for HIV. Half the subjects were exposed to a community-wide outreach intervention to prevent the spread of AIDS. Capitalizing on this one- year database and continuing access to the sample, the proposal aims to produce a five-year longitudinal study by conducting four more yearly follow-up interviews and HIV tests. The current staff has achieved a high follow-up rate with these subjects in the last wave of interviews, and the project files have extensive location information on the subjects. The study therefore anticipates completing follow-ups with 90% of the subjects each-year, and will use new analysis techniques to adjust for attrition. The resulting data will be used to assess the long-term effectiveness of AIDS prevention, determine the stability of changes in risk behaviors, describe the sero-conversion rate over time, and prospectively study the tendency of the infection rate to level off. The project will also use a computerized map to analyze the data on residence and HIV status in order to track the epidemic geographically over time, and will examine the impact of AIDS on homeless and non- homeless IVDUs over time.