LONG TERM EFFECTS ON OFFSPRING OF CHRONIC CANNABIS

这项提案寻求三年的资金，以进行医疗 对五十六对母子进行人类学随访研究， 是之前一项研究中的受试者， 怀孕期间使用大麻对儿童健康和发育的影响 牙买加农村大麻使用人群中的新生儿。 在 早期的研究，大麻吸烟的母亲与非 按年龄、性别和产次分列的吸食大麻的母亲。 他们的 随后使用Brazelton Neonatal 评估量表。 这项拟议中的研究将比较儿童 吸烟妇女与非吸烟妇女的子女的比例 五岁的女性在发育和行为方面 样式的 麦卡锡儿童能力量表（McCarthy Scale of Children Abilities） （MSCA）和行为方式问卷（BSQ），分别， 将用于 由于早期的研究表明， 在缓解一些潜在的 大麻的不良影响，拟议的研究将比较 两组儿童在五岁时的生存环境。 的 环境将通过使用考德威尔家庭量表进行评估 通过训练有素的人种学家的直接观察， 开展以社区和家庭为基础的实地研究。 数据将通过多变量方差分析进行分析 （MANOVA）使用每个工具（MSCA，BSQ，HOME）的子评分， 考虑到大麻的使用与剂量有关。 轮廓 将对各组进行分析。 经典相关性和 逐步多元回归将提供关于家庭的数据，因为它 与BSQ和MSCA有关。 牙买加的环境允许研究的长期影响， 大麻用于怀孕期间吸烟的母亲的孩子， 不受其他有害物质或重酒精的干扰， 烟草消费。

This proposal seeks funding for three years to conduct a medical anthropological follow-up study of fifty-six mother-child dyads who were subjects in a previous study that compared the effects of marihuana use during pregnancy on the health and development of the neonate in a cannabis-using population in rural Jamaica. In the earlier study, cannabis smoking mothers were matched with non- cannabis smoking mothers according to age, sex, and parity. Their offspring were subsequently evaluated using the Brazelton Neonatal Assessment Scale. The proposed research will compare the children of cannabis-smoking women with the children of non-cannabis smoking women at age five with regard to their development and behavioral style. To this end, the McCarthy Scales of Childrens Abilities (MSCA) and the Behavioral Style Questionnaire (BSQ), respectively, will be used. Since the earlier study suggested the role of the caregiving environment in mitigating some of the potentially adverse effects of marihuana, the proposed study will compare the caregiving environments of the two groups at age five. The environments will be assessed by the use of the Caldwell HOME Scale and through direct observations by trained ethnographers who will conduct community-based and home-based field studies. The data will be analyzed by multivariate analysis of variance (MANOVA) using subscores on each of the tools (MSCA, BSQ, HOME) and considering marihuana use in dose related fashion. Profile analysis will be performed on groups. Cannonic correlations and step-wise multiple regression will provide data on the HOME as it relates to BSQ and MSCA. The Jamaican setting permits the study of the long-term effects of marihuana use on children of mothers who smoked during pregnancy, unconfounded by other illic substances or by heavy alcohol or tobacco consumption.