Development and Commercialisation of a Second Generation Rapid Diagnostic Test (RDT) for Human African Trypanosomiasis (HAT) and other Kinetoplastida

针对人类非洲锥虫病 (HAT) 和其他动质体的第二代快速诊断测试 (RDT) 的开发和商业化

• 批准号: BB/N012496/1
• 负责人: Christopher Smales
• 金额: $ 24.31万
• 依托单位: University of Kent
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FN012496%2F1
• 关键词: Development; Commercialisation; Second; Generation; Rapid

The overall aim of this research is to complete the further development and commercialisation of new tests for the detection and diagnosis of the parasite Human African Trypanosomiasis (HAT or sleeping sickness), building upon and completing previously funded BBSRC applications. HAT threatens 43.4 million people in the sub-Saharan area of Africa, is the result of infection by parasites transmitted by the tsetse fly, and the development of new, more reliable and economic diagnostic biomarkers and assays is essential, particularly for surveillance and to curb transmission in the remaining moderate to high risk foci. Our approach is also amenable to the development of new diagnostic tests for the diagnosis, monitoring and surveillance of other diseases caused by parasite diseases. We will therefore also apply our technology to the development of new diagnostic tests for other diseases caused by Trypanosomes and Kinetoplastid diseases of commercial and social importance.

这项研究的总体目标是在之前资助的BBSRC申请的基础上，完成对寄生虫人类非洲锥虫病(HAT或昏睡病)检测和诊断的新测试的进一步开发和商业化。威胁非洲撒哈拉以南地区4 340万人的艾滋病是采采蝇传播的寄生虫感染的结果，开发新的、更可靠和经济的诊断生物标志物和分析至关重要，特别是对于监测和遏制其余中到高风险疫源地的传播。我们的方法也适用于开发新的诊断测试，用于诊断、监测和监测由寄生虫病引起的其他疾病。因此，我们还将把我们的技术应用于开发其他由锥虫和动粒体病引起的新的诊断测试，这些疾病具有重要的商业和社会意义。

项目成果

Glycosylation of Trypanosoma cruzi TcI antigen reveals recognition by chagasic sera.

• DOI: 10.1038/s41598-020-73390-9
• 发表时间: 2020-10-02
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Murphy N;Rooney B;Bhattacharyya T;Triana-Chavez O;Krueger A;Haslam SM;O'Rourke V;Pańczuk M;Tsang J;Bickford-Smith J;Gilman RH;Tetteh K;Drakeley C;Smales CM;Miles MA
• 通讯作者: Miles MA