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TRANSITIONS AND TRANSPORT IN GASTRIC MUCOSA

TRANSITIONS AND TRANSPORT IN GASTRIC MUCOSA
胃粘膜的转变和运输
批准号：
3226425
负责人：
TERRY E MACHEN
金额：
$19.82万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
1977
资助国家：
美国
项目状态：
已结题
起止时间：
1977-04-01 至 1994-11-30
来源：
https://reporter.nih.gov/project-details/3226425
关键词：
acid base balance acidity /alkalinity adenosinetriphosphatase antihistamines bicarbonates calcium carbachol chlorine cyclic AMP exocytosis fluorescence spectrometry fluorescent dye /probe gastric mucosa gastrointestinal absorption /transport histamine homeostasis hydrogen image processing ion transport ionophores laboratory rabbit membrane permeability membrane potentials membrane transport proteins microspectrophotometry muscarinic receptor potassium protein kinase C second messengers secretion sodium

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英文摘要
The major goal of this work is to determine how the acid-secreting parietal cells of the rabbit stomach maintain ionic homeostasis during large changes in their secretory activity. Microspectrofluorimetry and digital image processing of pH-, Na- Ca-, Cl- and K-sensitive fluorescent dyes will be used to determine how the ion exchangers (Na/H, Cl/HCO3, and Na/Ca), cotransporter (Na/HCO3), ATP-ases (Na/K and H/K), and Ca "channels" are controlled by the H2 agonist histamine and muscarinic agonist carbachol. The roles which different second messengers like Ca, pH, CAMP and protein kinase C may play in stimulus secretion coupling will also be investigated, as will the roles which Na/H and Cl/HC03 exchange might play in maintenance of the "barrier" function of the enzyme-secreting chief cells and mucus-secreting surface epithelial cells. These data will be of importance in knowing how stomach cells operate in healthy and diseased states. Also, since the membrane transport processes and stimulus-secretion coupling mechanisms are present in most secretory cells, the work should have quite broad relevance.
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