VITAMIN SUPPLEMENTATION IN THE TREATMENT OF ORAL LESIONS

本提案的主要目的是评估 维生素补充剂（β-胡萝卜素，维生素C和维生素E）， 口腔粘膜病变的治疗。 具体来说，我们计划招募200名 口腔粘膜病变患者3年以上。 的 将获得以下数据：诊断性活检， 病变大小，临床照片，血清和组织样本，以确定 维生素水平、暴露于危险因素和饮食史。 将在1、3、6和9个月进行临床和生化评价 开始补充后。 这将允许统计 口腔病变变化与血液中维生素水平的比较 和组织，暴露于危险因素，和饮食。 基于样本 大小，重复测量方差分析的估计功效，以检测 四组之间的差异为81%，多项为86 逻辑分析 这项双盲随机临床试验的意义在于， 它将确定以这种剂量补充维生素是否能减少 口腔粘膜病变的大小。

The primary objective of this proposal is to evaluate the efficacy of vitamin supplementation (beta-carotene, vitamin C, and vitamin E) in the treatment of oral mucosal lesions. Specifically, we plan to recruit 200 patients with oral mucosal lesions over a three year period. The following data will be obtained: diagnostic biopsy, measurement of the lesion size, clinical photographs, serum and tissue samples to determine vitamin levels, exposure to risk factors, and diet history. Clinical and biochemical evaluations will occur 1, 3, 6, and 9 months after initiation of supplementation. This will permit a statistical comparison of changes in the oral lesions to vitamin levels in the blood and tissue, exposure to risk factors, and diet. Based on the sample size, the estimated power of the repeated measures ANOVA to detect a difference among the four groups is 81% and is 86% for multinomial logistic analysis. The significance of this double-blind randomized clinical trial is that it will determine if vitamin supplementation at this dosage can reduce the size or oral mucosal lesions.