The use of beta-lactams to prevent biofilm growth in durable nonwovens

使用 β-内酰胺防止耐用非织造布中生物膜的生长

• 批准号: BB/P000231/1
• 负责人: Chris Carr
• 金额: $ 6.31万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FP000231%2F1
• 关键词: use; beta; lactams; prevent; biofilm

Within the nonwovens sector personal and household care, hygiene, medical and filtration products are constantly challenged by microbial contamination. In durable nonwovens the hygiene problem is addressed mostly through anti-microbials such as silver and quaternary ammonium compounds. However these present environmental and toxicological risks, are of limited efficacy on biofilms, and also present a risk of increasing microbial resistance. Recently the screening of a library of over 600 furanone derived lactams has revealed variants that disrupt quorum sensing during biofilm growth and development. This feasibility project will explore the application of these as anti-biofilm coatings on nonwoven textiles. Using different application techniques during manufacture, analogues will be covalently and non-covalently bound within the matrices, or at the surface, of polyolefin and cellulosic materials. The efficacy and durability of the antifouling coating on nonwoven products will be explored and the possibility of a biotechnology platform that covers a range of applications across durable nonwoven market segments will be assessed.

在非织造布行业，个人和家庭护理、卫生、医疗和过滤产品不断受到微生物污染的挑战。在耐用非织造布中，卫生问题主要是通过抗微生物剂如银和季铵化合物来解决的。然而，这些目前的环境和毒理学风险，对生物膜的功效有限，而且还存在增加微生物耐药性的风险。最近，对600多个呋喃酮衍生内酰胺的筛选揭示了在生物膜生长和发育过程中破坏群体感应的变异。本可行性项目将探索其作为抗生物膜涂层在非织造布上的应用。在制造过程中使用不同的应用技术，类似物将在聚烯烃和纤维素材料的基质内或表面以共价和非共价结合。将探索非织造布产品防污涂层的功效和耐久性，并评估涵盖耐用非织造布市场领域的一系列应用的生物技术平台的可能性。