STUDIES ON THE SPHINCTER OF ODDI AND GALLBLADDER
ODI 括约肌和胆囊的研究
基本信息
- 批准号:3228278
- 负责人:
- 金额:$ 10.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1980
- 资助国家:美国
- 起止时间:1980-09-01 至 1988-06-30
- 项目状态:已结题
- 来源:
- 关键词:adrenergic agents antiadrenergic agents biliary tract disorder biliary tract disorder chemotherapy biliary tract pharmacology cholecystokinin duodenum electromyography electrophysiology electrostimulus gallbladder gastrointestinal hormones gastrointestinal motility /pressure hormone regulation /control mechanism immunopharmacology innervation neurohormones reflex sympathetic nervous system tissue /cell culture
项目摘要
The broad objectives of this proposal are to investigate the neurohormonal
mechanisms involved in the regulation of the sphincter of Oddi (SO) and
gallbladder (GB) motor function and in the physiological interaction
between the duodenum and the biliary tract. These studies will be
performed in vitro in the muscle bath and in vivo in an isolated
duodenal-biliary tract preparation in cats. SO, GB, and duodenal motor
function will be determined by measuring mechanical and myoelectrical
activity. Our major areas of interest are: 1) analysis of the
myoelectrical patterns during basal and stimulated states to determine the
extent of electro-mechanical coupling and dissociation and their effects on
SO flow rates; 2) pharmacological characterization of receptors of duodenal
hormones and neurotransmitters which may participate in the physiological
control of the basal or stimulated biliary tract motor function; 3) we will
extend our studies of the nature of the intrinsic neural pathways and
demonstrate the extrinsic innervation of the biliary tract in order to make
possible the study of reflex mechanisms between the duodenum and the
biliary tract; 4) we will investigate neurohormonal relationships to define
the nature of the interaction between duodenal hormones (CCK, motilin) and
the vagus and sympathetic nerves. These studies will permit us to examine
possible types of interaction, that is, of potentiation or antagonism which
will increase our understanding of what is a physiological stimulus and to
develop models of biliary dysfunction; and 5) we will pursue these studies
further by examining these neurohormonal relationships under physiological
conditions by stimulating the release of endogenous duodenal hormones
and/or the activation of reflexes.
这项提议的主要目标是研究神经激素
参与调节Oddi括约肌(SO)和
胆囊(GB)运动功能与生理的相互作用
在十二指肠和胆道之间。这些研究将是
在体外进行的肌肉浴和在体内的隔离
猫十二指肠胆道准备。所以,国标和十二指肠运动
功能将通过测量机械和肌电来确定
活动。我们主要感兴趣的领域是:1)分析
基础状态和刺激状态下的肌电模式以确定
机电耦合和解离的程度及其对环境的影响
SO流量;2)十二指肠受体的药理学特性
激素和神经递质可能参与生理性的
控制基础或刺激的胆道运动功能;3)我们将
扩展我们对内在神经通路的本质的研究
演示胆道的外在神经支配,以使
十二指肠和十二指肠之间反射机制的可能研究
胆道;4)我们将研究神经激素的关系,以确定
十二指肠激素(CCK、胃动素)与胃动素相互作用的本质
迷走神经和交感神经。这些研究将使我们能够检查
可能的相互作用类型,即增强或拮抗
将增加我们对什么是生理刺激的理解,并
发展胆道功能障碍的模型;5)我们将继续这些研究
进一步通过在生理状态下检查这些神经激素关系
刺激内源性十二指肠激素释放的条件
和/或反射的激活。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOSE BEHAR其他文献
JOSE BEHAR的其他文献
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{{ truncateString('JOSE BEHAR', 18)}}的其他基金
Role of Progesterone in Colonic Muscle Dysfunction
黄体酮在结肠肌肉功能障碍中的作用
- 批准号:
6989786 - 财政年份:2004
- 资助金额:
$ 10.28万 - 项目类别:
Role of Progesterone in Colonic Muscle Dysfunction
黄体酮在结肠肌肉功能障碍中的作用
- 批准号:
6849229 - 财政年份:2004
- 资助金额:
$ 10.28万 - 项目类别:
Role of Progesterone in Colonic Muscle Dysfunction
黄体酮在结肠肌肉功能障碍中的作用
- 批准号:
7331463 - 财政年份:2004
- 资助金额:
$ 10.28万 - 项目类别:
Role of Progesterone in Colonic Muscle Dysfunction
黄体酮在结肠肌肉功能障碍中的作用
- 批准号:
7163438 - 财政年份:2004
- 资助金额:
$ 10.28万 - 项目类别:
Role of Progesterone in Colonic Muscle Dysfunction
黄体酮在结肠肌肉功能障碍中的作用
- 批准号:
6725171 - 财政年份:2004
- 资助金额:
$ 10.28万 - 项目类别:
MUSCLE CONTRACTION IN HUMAN & PRAIRIE DOG GALLBLADDERS
人体肌肉收缩
- 批准号:
3228276 - 财政年份:1980
- 资助金额:
$ 10.28万 - 项目类别:
STUDIES ON THE SPHINCTER OF ODDI AND GALLBLADDER
ODI 括约肌和胆囊的研究
- 批准号:
3228277 - 财政年份:1980
- 资助金额:
$ 10.28万 - 项目类别: