MAGNETIC MEASUREMENT OF HUMAN IRON STORES

人体铁储备的磁力测量

• 批准号: 3227291
• 负责人: JOHN W HARRIS
• 金额: $ 21.07万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-12-01 至 1989-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3227291
• 关键词: adult human (21+); alcoholism /alcohol abuse; biopsy; blood transfusion; cancer complication; chelation therapy; child (0-11); clinical biomedical equipment; computer assisted diagnosis; congenital hepatic porphyria; early diagnosis; ferritin; hemodialysis; hemosiderosis; hereditary hemochromatosis; human subject; iron disorder; iron storage disorder; liver cirrhosis; liver disorder diagnosis; magnetic field; metabolism disorder diagnosis; noninvasive diagnosis; orphan disease /drug; sickle cell anemia; sideroblastic anemia; thalassemia

The proposed research will use biomagnetic susceptometry - a method introduced and developed by our laboratories - to measure hepatic storage iron concentrations in patients with disorders of iron metabolism. At present, the results of non-invasive magnetic determinations and of the chemical analysis of hepatic tissue obtained by biopsy are quantitatively equivalent when body iron stores are normal or increased. With our new computer-enhanced, dual channel, superconducting quantum-interference device (SQUID) susceptometer, a computer controls the entire measurement procedure and automatically calculates the hepatic iron concentration. In effect, the susceptometric method provides an automated, safe, and non-invasive magnetic "biopsy" of liver ferritin and hemosiderin iron that is well accepted by patients. In patients with iron overload, magnetic studies permit accurate, direct, reliable, and repeated measurements of hepatic iron that are not possible with any other available method. Clinically, hepatic magnetic measurements will be used for the detection and serial monitoring of patients with iron overload. In hereditary hemochromatosis, magnetic determinations of hepatic iron stores can identify affected individuals at an early precirrhotic stage when conventional indirect measures of iron status (serum, ferritin, transferrin saturation) may be unreliable and make possible early, preventive phlebotomy therapy. Magnetic measurements provide a new means for rapidly determining the effectiveness of treatment programs (chelation, transfusion) in transfusional iron overload (thalassemia major, other refractory anemia). Studies using the new dual channel instrument have already provided new quantitative insights that make possible the prescription of optimal individualized chelation regimens for patients with transfusional iron overload. Other studies are directed toward evaluating the toxicity of iron in patients with sickle cell anemia transfused for the prevention of recurrent stroke and in patients with iron-loading anemias with non-transfusional iron excess. In porphyria cutanea tarda, the relationship of clinical manifestations to hepatic iron content will be assessed during phlebotomy therapy. The prevalence and magnitude of iron overload in alcoholic cirrhosis and in patients requiring chronic hemodialysis will be examined in our hospital population. The goal of our studies is to determine directly the quantitative relationship between the level of iron stores and the pathophysiologic manifestations of disorders of iron metabolism.

这项拟议的研究将使用生物磁测磁法--一种方法 由我们的实验室引进和开发-用于测量肝脏存储 铁代谢紊乱患者的铁浓度。在… 目前，非侵入性磁性测定的结果和 通过活检获得的肝组织的化学分析是定量的 当体内铁储备正常或增加时，等量。使用我们的新产品 计算机增强的双通道超导量子干涉 装置(SQUID)感受器，计算机控制整个测量 程序，并自动计算肝脏铁浓度。在……里面 效果，这种感受度测量方法提供了一种自动化、安全和 肝脏铁蛋白和含铁血黄素的非侵入性磁性“活组织检查” 被患者很好地接受。在铁负荷过高的患者中，磁性 研究允许准确、直接、可靠和重复地测量 肝脏铁，这是任何其他可用的方法都不可能的。 临床上，将使用肝脏磁测量进行检测。 以及对铁超载患者的连续监测。世袭的 血色沉着症，肝脏铁储存的磁学测定可以 在肝硬变前的早期阶段识别受影响的个体 铁状态的常规间接测量(血清、铁蛋白、转铁蛋白 饱和)可能是不可靠的，并使及早预防成为可能 静脉抽液疗法。磁测量提供了一种新的快速测量手段 确定治疗方案的有效性(螯合， 输血铁超载(重型地中海贫血，其他 顽固性贫血)。使用新的双通道仪器的研究已经 已经提供了新的量化见解，使 红斑狼疮患者最佳个体化螯合方案的处方 输血铁超载。其他研究针对的是评估 铁剂对镰状细胞性贫血患者的毒性作用 预防卒中复发和铁负荷性贫血 非输血性铁过多。在迟发性皮肤卟啉菌中， 临床表现与肝脏铁含量的关系将是 在抽血治疗期间进行评估。铁的盛行率和数量 酒精性肝硬变和慢性肝炎患者的超负荷 血液透析将在我们医院的人群中进行检查。我们的目标是 研究的目的是直接确定两者之间的数量关系 铁储备水平与疾病的病理生理表现 铁的新陈代谢。