HUMAN ERYTHROCYTE MEMBRANE CYTOSKELETON ASSOCIATIONS
HUMAN ERYTHROCYTE MEMBRANE CYTOSKELETON ASSOCIATIONS
批准号:
3229056
负责人:
G Vann Bennett
金额:
$19.95万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1987
资助国家:
美国
项目状态:
已结题
起止时间:
1987-09-01 至 1991-03-31
关键词:
Plasmodium falciparum ankyrins band 3 protein binding proteins calcium calmodulin clathrin cow crosslink cytoskeleton electron microscopy erythrocyte membrane erythroleukemia gel electrophoresis human tissue laboratory rabbit malaria membrane proteins phosphorylation protein structure radioimmunoassay radiotracer spectrin transferrin transferrin receptor virulence
中文摘要
这项提议的目标是a)进一步详细地阐明
人红细胞膜蛋白质的分子间相互作用
骨骼;b)确定红细胞膜蛋白如何组装
发展;c)使用红细胞膜作为实验
用于了解膜结构和功能的易访问模型系统
在更复杂的细胞中。另一个新的感兴趣的领域是
恶性疟原虫侵袭人红细胞的机制
寄生虫。一般而言,这些研究将在以下情况下进行
已经纯化和鉴定的膜蛋白,以及
这些蛋白质之间的关联性将被定量评估。
具体项目有以下几个方面:1)研究
红细胞Anykrin和Anyrin的蛋白水解物片段
血影蛋白的定义寡聚态和条带的胞质结构域
3.2)一种新发现的钙调素结合蛋白的研究
红细胞膜骨架的组成及其测定的目的
它的蛋白质结合,以及钙对这些结合的调节
和钙调蛋白。3)将RBC评价作为模型系统进行研究
受体介导的内吞作用中的蛋白质关联,使用
最近从红细胞胞浆中纯化,转铁蛋白受体从
胎盘。4)迄今尚未鉴定的红细胞蛋白质的研究
包括提纯、最近邻分析和寻找异构体
在其他组织中。候选者将是Band 4.2,一种膜骨架形式的
带7和最近发现的钙调蛋白结合蛋白。5)组装
红白血病分化过程中红细胞膜骨架的变化
细胞。6)人红细胞侵袭机制的研究
恶性疟原虫裂殖子及裂殖子的纯化
与条带3相互作用的蛋白质。
英文摘要
The goals of this proposal are to a) elucidate in further detail the
intermolecular associations of proteins of the human erythrocyte membrane
skeleton; b) determine how membrane proteins assemble during erythroid
development; c) use the erythrocyte membrane as an experimentally
accessible model system for understanding membrane structure and function
in more complex cells. An additional, new area of interest is the
mechanism of invasion of human erythrocytes by P. falciparum malarial
parasites. As a general approach, these studies will be performed with
membrane proteins that have been purified and characterized, and
associations between these proteins will be evaluated quantitatively.
Specific projects are in the following areas: 1) Studies of binding of
erythrocyte anykrin and proteolytic fragments of ankyrin in solution to
defined oligomeric states of spectrin and the cytoplasmic domain of band
3. 2) Studies of a newly discovered calmodulin-binding protein that is a
component of the erythrocyte membrane skeleton with goals of determining
its protein associations, and regulation of these associations by calcium
and calmodulin. 3) Evaluation of the RBC as a model system to study
protein associations in receptor-mediated endocytosis, using clathrin that
has recently been purified from RBC cytosol, and transferrin receptor from
placenta. 4) Studies of heretofore uncharacterized erythrocyte proteins
including purification, nearest neighbor analysis and search for isoforms
in other tissues. Candidates will be band 4.2, a membrane skeletal form of
band 7 and a recently discovered calmodulin-binding protein. 5) Assembly
of an erythroid membrane skeleton during differentiation of erythroleukemia
cells. 6) Studies of the mechanisms of invasion of human erythrocytes by
merozoites of P. falciparum, with emphasis on purification of merozoite
proteins that interact with band 3.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Deciphering high function autism using mice with human de novo ANK2 mutations
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批准号:9429362
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项目类别:
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资助金额:$23.88万
-
财政年份:2017
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负责人:G Vann Bennett
-
依托单位:
ERYTHROCYTE MEMBRANE CYTOSKELETON ASSOCIATIONS
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批准号:2684112
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项目类别:
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资助金额:$25.42万
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财政年份:1987
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负责人:G Vann Bennett
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依托单位:
ERYTHROCYTE MEMBRANE CYTOSKELETON ASSOCIATIONS
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批准号:2391339
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项目类别:
-
资助金额:$24.44万
-
财政年份:1987
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负责人:G Vann Bennett
-
依托单位:
ERYTHROCYTE MEMBRANE CYTOSKELETON ASSOCIATIONS
-
批准号:2138239
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项目类别:
-
资助金额:$5.34万
-
财政年份:1987
-
负责人:G Vann Bennett
-
依托单位:
HUMAN ERYTHROCYTE MEMBRANE CYTOSKELETON ASSOCIATIONS
-
批准号:3229055
-
项目类别:
-
资助金额:$13.8万
-
财政年份:1987
-
负责人:G Vann Bennett
-
依托单位:
ERYTHROCYTE MEMBRANE CYTOSKELETON ASSOCIATIONS
-
批准号:2138240
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项目类别:
-
资助金额:$20.63万
-
财政年份:1987
-
负责人:G Vann Bennett
-
依托单位:
GORDON CONFERENCE ON THE RED CELL
-
批准号:3435624
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项目类别:
-
资助金额:$1.0万
-
财政年份:1987
-
负责人:G Vann Bennett
-
依托单位:
HUMAN ERYTHROCYTE MEMBRANE CYTOSKELETON ASSOCIATIONS
-
批准号:3229054
-
项目类别:
-
资助金额:$7.02万
-
财政年份:1987
-
负责人:G Vann Bennett
-
依托单位:
ERYTHROCYTE MEMBRANE CYTOSKELETON ASSOCIATIONS
-
批准号:2138237
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项目类别:
-
资助金额:$20.12万
-
财政年份:1987
-
负责人:G Vann Bennett
-
依托单位:
HUMAN ERYTHROCYTE MEMBRANE CYTOSKELETON ASSOCIATIONS
-
批准号:3483522
-
项目类别:
-
资助金额:$18.75万
-
财政年份:1987
-
负责人:G Vann Bennett
-
依托单位:
HUMAN ERYTHROCYTE MEMBRANE CYTOSKELETON ASSOCIATIONS
-
批准号:3483523
-
项目类别:
-
资助金额:$19.34万
-
财政年份:1987
-
负责人:G Vann Bennett
-
依托单位:
HUMAN ERYTHROCYTE MEMBRANE CYTOSKELTON ASSOCIATIONS
-
批准号:3229057
-
项目类别:
-
资助金额:$6.33万
-
财政年份:1987
-
负责人:G Vann Bennett
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依托单位:
PROTEIN ASSOCIATIONS OF BRAIN SPECTRIN AND ANKYRIN
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批准号:3284314
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项目类别:
-
资助金额:$7.87万
-
财政年份:1987
-
负责人:G Vann Bennett
-
依托单位:
HUMAN ERYTHROCYTE MEMBRANE CYTOSKELETON ASSOCIATIONS
-
批准号:3483521
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项目类别:
-
资助金额:$17.99万
-
财政年份:1987
-
负责人:G Vann Bennett
-
依托单位:
PROTEIN ASSOCIATIONS OF BRAIN SPECTRIN AND ANKYRIN
-
批准号:3284313
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项目类别:
-
资助金额:$6.23万
-
财政年份:1987
-
负责人:G Vann Bennett
-
依托单位:
ERYTHROCYTE MEMBRANE CYTOSKELETON ASSOCIATIONS
-
批准号:2138238
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项目类别:
-
资助金额:$21.29万
-
财政年份:1987
-
负责人:G Vann Bennett
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依托单位:
PROTEIN ASSOCIATIONS OF BRAIN SPECTRIN AND ANKYRIN
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批准号:3284311
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项目类别:
-
资助金额:$13.19万
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财政年份:1984
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负责人:G Vann Bennett
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依托单位:
PROTEIN ASSOCIATIONS OF BRAIN SPECTRIN AND ANKYRIN
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批准号:3284312
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项目类别:
-
资助金额:$3.22万
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财政年份:1984
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负责人:G Vann Bennett
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依托单位:
PROTEIN ASSOCIATIONS OF BRAIN SPECTRIN AND ANKYRIN
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批准号:3284310
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项目类别:
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资助金额:$12.7万
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财政年份:1984
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负责人:G Vann Bennett
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依托单位:
INTERACTION OF ERYTHROCYTE MEMBRANE PROTEINS
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批准号:3071095
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项目类别:
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资助金额:$5.36万
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财政年份:1981
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负责人:G Vann Bennett
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依托单位:
海外基金