High-throughput technology targeting antimicrobial resistance in animals

针对动物抗菌素耐药性的高通量技术

• 批准号: LE170100093
• 负责人: Prof Darren Trott
• 金额: $ 34.01万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2018-07-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE170100093
• 关键词: throughput; technology; targeting; antimicrobial; resistance

This project aims to establish reference laboratories as biobanks for resistant isolate collections from veterinary diagnostic laboratories / surveillance programmes and a national research network to mitigate antimicrobial resistance in animals. Antimicrobial resistance in zoonotic/foodborne pathogens and livestock commensals is a global issue. This project will use mass-spectroscopy biotypers, information management software, robotic liquid handling and a research dairy to develop high-throughput screening technologies to rapidly determine major animal species’ resistance status, and research anti-infectives and vaccines for livestock diseases. This will improve the health and production of Australian livestock, leading to greater market access for high quality products.

该项目旨在建立参考实验室，作为从兽医诊断实验室/监测方案收集的耐药分离株的生物库，并建立一个国家研究网络，以减轻动物的抗菌素耐药性。人畜共患病/食源性病原体和家畜病原体的抗菌素耐药性是一个全球性问题。该项目将使用质谱生物型、信息管理软件、机器人液体处理和研究奶牛场来开发高通量筛选技术，以快速确定主要动物物种的抗性状况，并研究牲畜疾病的抗感染药物和疫苗。这将改善澳大利亚牲畜的健康和生产，从而为高质量产品提供更大的市场准入。