HORMONES IN THE EPIDEMIOLOGY OF PROSTATIC HYPERPLASIA

前列腺增生流行病学中的激素

• 批准号: 2139562
• 负责人: WENDY VERHOEK-OFTEDAHL
• 金额: $ 26.73万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-03-01 至 1995-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2139562
• 关键词: alcoholic beverage consumption; benign prostate hyperplasia; blood chemistry; carotenoids; dietary fiber; dietary lipid; dihydrotestosterone; disease /disorder proneness /risk; environmental health; epidemiology; estradiol; estrone; histopathology; hormone regulation /control mechanism; human old age (65+); interview; nutrient intake activity; nutrition related tag; patient /disease registry; prolactin; prostate surgery; questionnaires; saturated fat; testosterone; tobacco abuse; urinary tract obstruction

The long-term goal of this study is the development of preventive or therapeutic measure for benign prostatic hyperplasia (BPH). The specific aims are to evaluate the relations of the hormone profile to surgery for BPH, to evaluate the associations of cigarette smoking with hormone levels, and to evaluate associations of smoking and other environmental factors, especially diet, to BPH and to the hormone profile. A case- control study is proposed. The case series will be 500 men living in Rhode Island who have their first operation for BPH in the period May, 1989 - April, 1992. A series of 1,000 controls will be selected from residents of the study area. Subjects will be interviewed at home with respect to smoking and dietary histories. The dietary history will use the food frequency method supplemented with food models to help estimate portion size. Subjects will also be asked for blood specimens before and after the interview. Serum from each subject will be pooled and analyzed for free and bound testosterone, dehydrotestosterone, free and bound estradiol, estrone, delta4-androstenedione, androstanediol, and prolactin. The relative incidence of surgically-confirmed BPH will be estimated according to quintile of hormone levels, and according to smoking history and intakes of nutrients including total fat, saturated fat, carotenoids and fiber. Based on information from the controls, cigarette smoking and nutrient intakes will be related to hormone levels.

本研究的长期目标是开发预防性或 前列腺增生症（BPH）的治疗措施。 具体 目的是评估激素水平与手术的关系， 前列腺增生，评估吸烟与激素的关系 水平，并评估吸烟和其他环境因素之间的关系， 因素，特别是饮食，BPH和激素的配置文件。 一个案子- 建议进行对照研究。 这个病例系列将是500名居住在 罗得岛的人在五月进行了他们的第一次BPH手术， 1989年至1992年4月。 一系列的1，000个控制将从 研究区的居民。 受试者将在家中接受访谈， 吸烟史和饮食史。 饮食史将使用 食物频率法辅以食物模型， 份量 还将要求受试者在术前和术后采集血液样本， 在采访之后。 将合并并分析每例受试者的血清 游离和结合睾酮脱氢睾酮 雌二醇、雌酮、δ 4-雄烯二酮、雄甾烷酮和 催乳素 经病理证实的BPH的相对发病率为 根据激素水平的五分位数估计， 吸烟史和营养素摄入量，包括总脂肪、饱和脂肪酸 脂肪类胡萝卜素和纤维 根据控制系统的信息， 吸烟和营养摄入量将与激素水平有关。