课题基金 / 基金详情

CORTICOTROPIN-RELEASING HORMONE PHYSIOLOGY

CORTICOTROPIN-RELEASING HORMONE PHYSIOLOGY
促肾上腺皮质激素释放激素生理学
批准号:
3231745
负责人:
DAVID N ORTH
金额:
$19.85万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1983
资助国家:
美国
项目状态:
已结题
起止时间:
1983-12-01 至 1991-06-30

项目摘要

项目成果

DAVID N ORTH的其他基金

相似基金

相关文献

中文摘要
翻译
这个研究项目的总体目标是进一步定义
英文摘要
The overall objective of this research project is to define further the normal and abnormal physiology of corticotropin-releasing hormone (CRH). The efficacy of CRH stimulation during bilateral inferior petrosal vein sampling for plasma immunoreactive (IR) ACTH as a diagnostic test for differentiating Cushing's disease from ectopic ACTH syndrome and/or lateralizing pituitary microadenomas causing Cushing's disease will be evaluated. The intraoperative use of a fluorescent analog of human CRH (hCRH) to identify ACTH-secreting microadenomas either after they have been removed or in situ will be explored in vitro with excised human pituitary tumor tissue and in vivo in animals prior to possible clinical trials. A high molecular weight "IR-hCRH" in plasma, which may be an aggregate, a precursor, an hCRH- degrading enzyme or a specific carrier protein, will be characterized, and its effect on CRH bioactivity will be determined. The possible proliferative effects of chronic exposure to CRH on pituitary corticotrophs will be investigated in vivo in an animal model in which ovine CRH is infused intracerebroventricularly, and in vitro in dispersed rat anterior pituitary cell cultures. The fine temporal features of regulation of ACTH secretion by CRH and other agonists and antagonists of ACTH secretion and the interactions between the intracellular signal transduction pathways that mediate the actions of CRH, arginine vasopressin and other modulators of ACTH secretion will be elucidated in a dispersed cell microperifusion column system.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
Role of lipoxygenase metabolites of arachidonic acid in the regulation of adrenocorticotropin secretion by perifused rat anterior pituitary cells.
花生四烯酸脂氧合酶代谢物在调节灌注大鼠垂体前叶细胞促肾上腺皮质激素分泌中的作用。
DOI: 10.1210/endo.135.4.7523100
发表时间: 1994
期刊: Endocrinology
影响因子: 4.8
作者: [Won,JG, Orth,DN]
通讯作者: Orth,DN
Effect of protein kinase-C depletion on inositol trisphosphate-mediated and cyclic adenosine 3',5'-monophosphate-dependent protein kinase-mediated adrenocorticotropin secretion.
蛋白激酶 C 消耗对肌醇三磷酸介导的和环腺苷 3,5-单磷酸依赖性蛋白激酶介导的促肾上腺皮质激素分泌的影响。
DOI: 10.1210/endo.133.3.8396015
发表时间: 1993
期刊: Endocrinology
影响因子: 4.8
作者: [Won,JG, Nicholson,WE, Ching,KN, Orth,DN]
通讯作者: Orth,DN
NORMAL AND ABNORMAL HYPOTHALAMIC PITUITARY ADRENAL FUNCTION IN CUSHINGS
  • 批准号:
    6246691
  • 项目类别:
  • 资助金额:
    $3.1万
  • 财政年份:
    1997
  • 负责人:
    DAVID N ORTH
  • 依托单位:
CORE--HORMONE ASSAY
  • 批准号:
    6108199
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    1996
  • 负责人:
    DAVID N ORTH
  • 依托单位:
CRH'S ROLE IN CAUSE AND RECOVERY FROM HYPERCORTISOLISM
  • 批准号:
    2145277
  • 项目类别:
  • 资助金额:
    $22.01万
  • 财政年份:
    1994
  • 负责人:
    DAVID N ORTH
  • 依托单位:
CRH'S ROLE IN CAUSE AND RECOVERY FROM HYPERCORTISOLISM
  • 批准号:
    2145276
  • 项目类别:
  • 资助金额:
    $21.17万
  • 财政年份:
    1994
  • 负责人:
    DAVID N ORTH
  • 依托单位:
海外基金