CLINICAL TRIALS ON HUMAN ISLET TRANSPLANTATION

描述：(改编自申请人的摘要)第一个具体 此应用程序的目的是确定有多少胰岛素依赖型糖尿病 糖尿病患者可以通过胰岛移植实现胰岛素独立， 以及他们的移植物在两组患者中能持续多长时间。第一 研究是移植7天，24℃培养，超低温保存 已建立肾脏移植的I型患者在7天内进入胰岛 MALG和基础免疫抑制。第二项研究是移植7 天，24℃培养和冷冻保存的胰岛进入患者体内 他们的肾移植。有了这些信息，下一步 将决定免疫改变技术的能力 无长期免疫抑制的移植。第二个具体问题 目的是将培养7天、冷冻保存的胰岛移植到I型胰岛 进入肾功能衰竭的患者将接受胰岛治疗 培养和冷冻保存，多个供体，紫外线治疗，或者 移植前的特异性抗II类抗体。成功者 这些研究的完成将决定以下项目的实际可行性 胰岛移植以达到其远期目标。

DESCRIPTION: (Adapted from the applicant's abstract) The first specific aim of this application is to determine how many insulin dependent diabetes mellitus patients can achieve insulin independence by islet transplants, and how long their grafts will last, in two groups of patients. The first study is to transplant 7 day, 24 degrees C cultured and cryopreserved islets into Type I patients with established kidney transplants with 7 days of MALG and basal immunosuppression. The second study is to transplant 7 day, 24 degrees C cultured and cryopreserved islets into patients getting their kidney transplant. With this information obtained, the next step will be to determine the ability of immunoalteration techniques to permit transplantation without long term immunosuppression. The second specific aim is to transplant 7 day cultured, cryopreserved islets into Type I patients entering renal failure who will have their islets treated with either culture and cryopreservation, multiple donors, UV light therapy, or specific anti-class II antibodies prior to transplantation. The successful completion of these studies will determine the practical feasibility of islet transplantation to achieve its long term objective.