A NEW APPROACH TO VERSICOLORIN TYPE AFLATOXIN PRECURSORS
A NEW APPROACH TO VERSICOLORIN TYPE AFLATOXIN PRECURSORS
批准号:
3251732
负责人:
MICHAEL P CAVA
金额:
$6.43万
依托单位国家:
美国
项目类别:
财政年份:
1985
资助国家:
美国
项目状态:
已结题
起止时间:
1985-07-01 至 1987-01-31
中文摘要
黄曲霉毒素是一组高度致癌的真菌毒素,
由各种曲霉产生,并构成严重的
作为食品污染物的健康危害。它们的生物起源,这仍然不是
完全阐明,涉及一系列复杂的转换
从2-n-己基蒽醌的衍生物开始。作为这项工作的一部分
序列,在包括以下步骤的过程中将阿维夫芬转化为杂色苷A
一次不同寻常的侧链重排。
最近,我们发现了一种新的烷基取代的重排
我们认为它代表了第一个化学模型
向杂色苷A转化的关键一步。我们的现在
目标是详细探讨这种新的重组,重点是
杂色素型化合物的合成。
英文摘要
The aflatoxins are a group of highly carcinogenic mycotoxins which are
produced by various Aspergillus species, and which constitute serious
health hazards as food contaminants. Their biogenesis, which is still not
completely elucidated, involves a complex series of transformations
starting from derivatives of 2-n-hexylanthraquinone. As part of this
sequence, averufin is converted into versicolorin A in a process involving
an unusual side-chain rearrangement.
Recently, we discovered a new rearrangement of an alkyl-substituted
anthraquinone which we believe represents the first chemical model for the
crucial step in the averufin to versicolorin A transformation. Our present
objective is to explore this new rearrangement in detail, with emphasis on
the synthesis of compounds of the versicolorin type.
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会议论文
SYNTHESIS OF NOVEL MARINE HETEROCYCLES
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批准号:2182694
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项目类别:
-
资助金额:$17.06万
-
财政年份:1991
-
负责人:MICHAEL P CAVA
-
依托单位:
SYNTHESIS OF NOVEL MARINE HETEROCYCLES
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批准号:3303965
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项目类别:
-
资助金额:$15.98万
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财政年份:1991
-
负责人:MICHAEL P CAVA
-
依托单位:
SYNTHESIS OF NOVEL MARINE HETEROCYCLES
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批准号:3303967
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项目类别:
-
资助金额:$15.52万
-
财政年份:1991
-
负责人:MICHAEL P CAVA
-
依托单位:
SYNTHESIS OF NOVEL MARINE HETEROCYCLES
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批准号:3303968
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项目类别:
-
资助金额:$16.23万
-
财政年份:1991
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负责人:MICHAEL P CAVA
-
依托单位:
SYNTHESIS OF TROPLOISOQUINOLINE ALKALOIDS
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批准号:3298925
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项目类别:
-
资助金额:$6.8万
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财政年份:1988
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负责人:MICHAEL P CAVA
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依托单位:
SYNTHESIS OF TROPLOISOQUINOLINE ALKALOIDS
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批准号:3298926
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项目类别:
-
资助金额:$7.13万
-
财政年份:1988
-
负责人:MICHAEL P CAVA
-
依托单位:
SYNTHESIS OF TROPLOISOQUINOLINE ALKALOIDS
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批准号:3298923
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项目类别:
-
资助金额:$7.07万
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财政年份:1988
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负责人:MICHAEL P CAVA
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依托单位:
A PHOTOCHEMICAL APPROACH TO CC-1065 AND ANALOGS
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批准号:3182667
-
项目类别:
-
资助金额:$8.8万
-
财政年份:1985
-
负责人:MICHAEL P CAVA
-
依托单位:
A PHOTOCHEMICAL APPROACH TO CC-1065 AND ANALOGS
-
批准号:3182668
-
项目类别:
-
资助金额:$11.18万
-
财政年份:1985
-
负责人:MICHAEL P CAVA
-
依托单位:
A PHOTOCHEMICAL APPROACH TO CC-1065 AND ANALOGS
-
批准号:3182665
-
项目类别:
-
资助金额:$2.13万
-
财政年份:1985
-
负责人:MICHAEL P CAVA
-
依托单位:
A PHOTOCHEMICAL APPROACH TO CC-1065 AND ANALOGS
-
批准号:3182669
-
项目类别:
-
资助金额:$8.13万
-
财政年份:1985
-
负责人:MICHAEL P CAVA
-
依托单位:
A PHOTOCHEMICAL APPROACH TO CC-1065 AND ANALOGS
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批准号:3182662
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项目类别:
-
资助金额:$8.98万
-
财政年份:1985
-
负责人:MICHAEL P CAVA
-
依托单位:
A PHOTOCHEMICAL APPROACH TO CC-1065 AND ANALOGS
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批准号:3182666
-
项目类别:
-
资助金额:$8.15万
-
财政年份:1985
-
负责人:MICHAEL P CAVA
-
依托单位:
A NEW APPROACH TO VERSICOLORIN TYPE AFLATOXIN PRECURSORS
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批准号:3251731
-
项目类别:
-
资助金额:$9.09万
-
财政年份:1985
-
负责人:MICHAEL P CAVA
-
依托单位:
A NEW APPROACH TO VERSICOLORIN TYPE AFLATOXIN PRECURSORS
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批准号:3250699
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项目类别:
-
资助金额:$2.89万
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财政年份:1984
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负责人:MICHAEL P CAVA
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依托单位:
海外基金