REAL-TIME ANALYSES OF MAIT CELLS' RESPONSES TO INFECTION

实时分析 MAIT 细胞对感染的反应

• 批准号: BB/S005560/1
• 负责人: Patricia Barral
• 金额: $ 56.36万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FS005560%2F1
• 关键词: REAL; TIME; ANALYSES; MAIT; CELLS

Our immune system is composed by many different immune cells that function together in a coordinated fashion to protect us from disease. Immune cells are very dynamic and constantly patrol the body on the look-out for infectious virus and bacteria. Consequently, the correct location of immune cells in the body (being in the right place at the right time) is extremely important for them to be able to efficiently find and destroy invading pathogens. While for many years immune responses to pathogens could only be studied in vitro (outside the body), the recent development of novel microscopy techniques enables scientists to directly visualize -within the body and in real time- immune cells combating pathogens. Our research aims to take advantage of these novel techniques to provide unique insight into the processes that initiate immune responses to bacterial infections. We focus on a specific population of immune cells- so called MAIT cells- which are known to be important in fighting bacterial infections. However how, where and when MAIT cells find and destroy bacteria in vivo remain unknown. In this proposal we intend to provide this understanding, by using our combined expertise in microscopy, immunology and microbiology to reveal the molecules and processes by which MAIT cells fight bacterial infections and how in turn bacteria subvert the immune system to survive in the host. The findings of this proposal may serve as the foundation for novel therapeutic and prevention strategies to treat infectious diseases

我们的免疫系统是由许多不同的免疫细胞组成的，它们以一种协调的方式共同起作用，保护我们免受疾病的侵害。免疫细胞是非常活跃的，不断地在体内巡逻，寻找传染性病毒和细菌。因此，免疫细胞在体内的正确位置（在正确的时间处于正确的位置）对于它们能够有效地发现和摧毁入侵的病原体至关重要。虽然多年来对病原体的免疫反应只能在体外（体外）进行研究，但最近新显微镜技术的发展使科学家能够在体内直接实时地观察免疫细胞与病原体的斗争。我们的研究旨在利用这些新技术为启动细菌感染免疫反应的过程提供独特的见解。我们关注的是一种特定的免疫细胞群——所谓的MAIT细胞——已知它在对抗细菌感染方面很重要。然而，MAIT细胞在体内如何、何地、何时发现并消灭细菌仍不清楚。在本提案中，我们打算通过利用我们在显微镜，免疫学和微生物学方面的综合专业知识来揭示MAIT细胞对抗细菌感染的分子和过程，以及细菌如何反过来破坏免疫系统以在宿主中生存，从而提供这种理解。这一建议的发现可以作为治疗传染病的新治疗和预防策略的基础

项目成果

Type I interferons drive MAIT cell functions against bacterial pneumonia.

• DOI: 10.1084/jem.20230037
• 发表时间: 2023-10-02
• 期刊: JOURNAL OF EXPERIMENTAL MEDICINE
• 影响因子: 15.3
• 作者: Lopez-Rodriguez, Juan Carlos;Hancock, Steven J.;Li, Kelin;Crotta, Stefania;Barrington, Christopher;Suarez-Bonnet, Alejandro;Priestnall, Simon L.;Aube, Jeffrey;Wack, Andreas;Klenerman, Paul;Bengoechea, Jose A.;Barral, Patricia
• 通讯作者: Barral, Patricia

CD1d-dependent rewiring of lipid metabolism in macrophages regulates innate immune responses.

• DOI: 10.1038/s41467-022-34532-x
• 发表时间: 2022-11-07
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Brailey, Phillip M.;Evans, Lauren;Lopez-Rodriguez, Juan Carlos;Sinadinos, Anthony;Tyrrel, Victoria;Kelly, Gavin;O'Donnell, Valerie;Ghazal, Peter;John, Susan;Barral, Patricia
• 通讯作者: Barral, Patricia