Harnessing protein unfolding and aggregation in mechanotransduction

利用力转导中的蛋白质解折叠和聚集

• 批准号: BB/S007245/1
• 负责人: Benjamin Goult
• 金额: $ 56.08万
• 依托单位: University of Kent
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FS007245%2F1
• 关键词: Harnessing; protein; unfolding; aggregation; mechanotransduction

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前，GtR 中尚未提供所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但可能是因为它包含个人详细信息等敏感信息。

项目成果

TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity.

• DOI: 10.1083/jcb.202209010
• 发表时间: 2023-05-01
• 期刊: JOURNAL OF CELL BIOLOGY
• 影响因子: 7.8
• 作者: Gallego-Paez, Lina M.;Edwards, William J. S.;Chanduri, Manasa;Guo, Yanyu;Koorman, Thijs;Lee, Chieh-Yu;Grexa, Nina;Derksen, Patrick;Yan, Jie;Schwartz, Martin A.;Mauer, Jan;Goult, Benjamin Thomas
• 通讯作者: Goult, Benjamin Thomas

Talin rod domain-containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation.

• DOI: 10.1083/jcb.202005214
• 发表时间: 2021-09-06
• 期刊: The Journal of cell biology
• 作者: Cowell AR;Jacquemet G;Singh AK;Varela L;Nylund AS;Ammon YC;Brown DG;Akhmanova A;Ivaska J;Goult BT
• 通讯作者: Goult BT

Next generation protein-based materials capture and preserve projectiles from supersonic impacts

下一代蛋白质材料可捕获并保护弹丸免受超音速撞击

• DOI: 10.1101/2022.11.29.518433
• 发表时间: 2022
• 作者: Doolan J

Cancer associated talin point mutations disorganise cell adhesion and migration.

• DOI: 10.1038/s41598-020-77911-4
• 发表时间: 2021-01-11
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Azizi L;Cowell AR;Mykuliak VV;Goult BT;Turkki P;Hytönen VP
• 通讯作者: Hytönen VP

The MeshCODE to scale-visualising synaptic binary information.

• DOI: 10.3389/fncel.2022.1014629
• 发表时间: 2022
• 期刊: Frontiers in cellular neuroscience
• 影响因子: 5.3