INTERACTIONS OF DRUGS AND NOISE EXPOSURE

药物和噪音暴露的相互作用

• 批准号: 3250901
• 负责人: DENNIS MCFADDEN
• 金额: $ 12.52万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-05-15 至 1989-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3250901
• 关键词: acetaminophen; analgesics; antiinflammatory agents; aspirin; audiometry; auditory pathways; auditory threshold shift; dosage; drug adverse effect; human subject; ibuprofen; noise induced deafness; psychoacoustics

The temporary hearing loss induced by exposure to intense sounds is increased if a person takes moderate doses of aspirin or sodium salicylate for two or more days prior to the exposure. The implication of this outcome is that people who live or work in noisy environments and who use either of these drugs may be at greater risk of permanent hearing loss than are people who receive the same noise exposures, but do not use the drugs. Two other non-steroidal anti-inflammatory agents, sulindac and diflunisal, do not produce this effect when taken in comparable doses. The goal of the proposed research is to examine other common drugs of various types for their ability to potentiate exposure to intense sounds, and to further study the various effects of aspirin on the auditory system. The other drugs of primary interest are widely used anti-inflammatories and analgesics. Establishing the relative safety of these various aspirin subtitutes will be of value to consumers, and to physicians when prescribing drugs for patients who live or work in noisy environments. Knowing more about the various auditory effects of aspirin may provide insights into the basic mechanisms of hearing, and it definitely will allow a reasoned decision as to whether the aspirin-altered ear is an acceptable model of certain auditory pathologies. The basic methodology used is a variant on the standard procedure for studying noise-induced, temporary hearing loss. The intensity of a tone is increased across daily sessions until it produces the target amount of temporary hearing loss (14 plus or minus 3 dB). Once established for each subject individually, those intensities are used to determine baseline values of exposure-induced temporary hearing loss. Then the drug of interest is administered, the same exposure intensity is delivered, and the total temporary hearing loss induced is measured and compared to the baseline function. Each crew of four listeners typically serves in three drug conditions, run at two-week intervals. No exposure ever exceeds 110 dB for 15 minutes. The informed consent procedure includes an educational program of required lectures, films and readings.

暴露于强烈声音引起的暂时听力损失是 如果一个人服用中等剂量的阿司匹林或水杨酸钠 曝光前两天或更长时间。 这意味着 结果是在嘈杂环境中生活或工作的人使用 这些药物中的任何一种可能比永久性听力损失的风险更大 是接受相同噪音暴露但不使用药物的人。 另外两种非甾体类抗炎药，苏莱达克和差异， 当服用可比剂量时，请勿产生这种效果。 目标的目标 拟议的研究是检查各种类型的其他常见药物 他们增强暴露于强烈声音的能力，并进一步 研究阿司匹林对听觉系统的各种影响。 另一个 主要感兴趣的药物是广泛使用的抗炎药和 镇痛药。 建立这些各种阿司匹林的相对安全 字幕对消费者和医生都具有价值 为在嘈杂环境中生活或工作的患者开药。 了解阿司匹林的各种听觉效果的更多信息 洞悉听力的基本机制，它肯定会允许 关于改变阿司匹林的耳朵是否可以接受的合理决定 某些听觉病理的模型。 使用的基本方法是 用于研究噪声引起的临时性的标准程序的变体 听力损失。 每日会议之间的音调强度增加 直到产生临时听力损失的目标量（14 plus或 减去3 dB）。 一旦为每个主题建立，那些 强度用于确定暴露诱导的基线值 暂时的听力损失。 然后服用感兴趣的药物， 交付了相同的暴露强度，并且总临时听力损失 测量诱导并将其与基线函数进行比较。 每个船员 四个听众通常在三个药物条件下服务，为期两周 间隔。 没有暴露超过110 dB 15分钟。 告知 同意程序包括一项要求的教育计划， 电影和读物。