DETERMINANTS OF OPTIC AXON OUTGROWTH
视轴突生长的决定因素
基本信息
- 批准号:3260323
- 负责人:
- 金额:$ 15.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1984
- 资助国家:美国
- 起止时间:1984-03-01 至 1996-02-29
- 项目状态:已结题
- 来源:
- 关键词:antiantibody axon developmental neurobiology embryo /fetus eye transplantation fluorescence microscopy histology immunocytochemistry inferior colliculus laboratory mouse laboratory rat laminin nervous system regeneration neural cell adhesion molecules neurogenesis neuronal guidance optic tract phase contrast microscopy polylysine retinal ganglion superior colliculus synaptogenesis tissue /cell culture video recording system
项目摘要
DESCRIPTION (Investigator's Abstract): The applicants plan to study
conditions in the developing rodent brain necessary for supporting optic
axon outgrowth and for establishing appropriate terminal connections
between molecules known to support axonal outgrowth and the extension of
retinal ganglion cell axons. In addition, the applicants will examine the
conditions that produce optimal outgrowth and formation of connections by
retinae transplanted to ectopic sites in neonatal and fetal rodent brains.
One series of studies will focus on the outgrowth process itself and the
substrates that support it while the other will examine what factors
influence the ability of optic axons originating from transplants to
innervate visual centers, to compete with other optic inputs for target
space and to form topographic maps within visual centers.
Such information will provide insight into how the circuitry for optimal
visual function is established. It will also define the conditions
necessary for creating surrogate pathways to replace damaged primary optic
connections.
描述(研究者摘要):申请人拟参加研究
项目成果
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