Proposal for a Talos L120C G2 Transmission Electron Microscope

Crick是医学研究委员会、英国癌症研究中心、惠康信托基金和三所顶尖大学：伦敦大学学院、伦敦帝国理工学院和伦敦国王学院的合作伙伴。克里克立志成为世界领先的医学研究机构之一。克里克通过被称为科学运营的中央设施和功能，实现运营和研究效率以及规模经济，为克里克的所有研究人员提供访问尖端设备、用于研究的动物和实验室支持功能(如电子显微镜科学技术平台(EM STP))的机会。电子显微镜是生物科学研究的基本工具。它被用来对蛋白质、病原体、细胞和组织的结构进行成像，以帮助我们了解正常发育、疾病状态和治疗效果的生物过程。这项建议是为了一种新的透射电子显微镜，它将用于克里克正在进行的60-80个研究项目的最先进的成像实验。该显微镜还有一系列其他功能，包括自动图像拼接，允许我们查看大样本并以数字方式放大感兴趣的特征(如谷歌地图)；使用一种名为电子断层扫描的技术对样本进行更快、更自动化的三维成像；以及冷冻台，用于对包裹在冰中的样本进行成像，尽可能接近它们的生活状态。

The Crick is a partnership between the Medical Research Council, Cancer Research UK, the Wellcome Trust and three leading universities: UCL (University College London), Imperial College London and King's College London. The Crick aspires to be one of the world's leading medical research institutes. The Crick achieves operational and research efficiencies and economies-of-scale through centralised facilities and functions, known as Science Operations, that provide all researchers at the Crick, irrespective of affiliation, with access to cutting-edge equipment, animals for research and laboratory enabling functions such as the Electron Microscopy Science Technology Platform (EM STP).Electron microscopy is a fundamental tool in bioscience research. It is used to image the structure of proteins, pathogens, cells and tissues, to help us understand the biological processes of normal development, disease states, and the effect of therapies.This proposal is for a new transmission electron microscope that will be used for state-of-the-art imaging experiments for 60-80 research projects ongoing at the Crick. The microscope has a range of additional features, including automated image stitching to allow us to view large samples and digitally zoom into features of interest (like 'google maps'); faster, more automated, three-dimensional imaging of samples using a technique called electron tomography; and a cryo-stage for imaging samples encased in ice, as close to their living state as possible.