ELECTRORETINOGRAPHIC STUDIES IN DIABETIC RETINOPATHY

糖尿病患者的视网膜电图(ERG)异常 视网膜病变将被确定，并与视网膜病变的严重程度相关 以及其他视觉功能的改变(色觉和视野)。ERG 要测量的参数是暗适应的b波振幅 对符合Naka-Rushton理论的强度序列的响应 公式[(计算Rmax(最大响应)，K(半饱和 常数)、n(响应函数的斜率)]和ERG振荡 电势(幅度和隐含时间)。美国人的能力 视网膜电信号和其他视觉功能测试以识别有风险的眼睛 进展到更严重的视网膜病变阶段将在 250例糖尿病患者的5-9年纵向研究 早期治疗糖尿病视网膜病变的研究。单独的EGR参数和 结合Farnsworth-Munsell 100色调测试分数和Goldmann 基线时的视野分数将与随后的 增殖性糖尿病视网膜病变的进展。如果这些测试证明 具有预测价值，将来可以用来选择患者 具有高风险特征的人，以便更早或更多地 强有力的内科或外科治疗干预。

The electroretinographic (ERG) abnormalities associated with diabetic retinopathy will be determined and related to the severity of retinopathy and to other visual function changes (color vision and visual fields). ERG parameters to be measured are the dark adapted b-wave amplitudes in response to an intensity series fit to the theoretical Naka-Rushton equation [(to compute R max (maximum response), K (half-saturation constant), n (slope of response function)], and the ERG oscillatory potentials (amplitude and implicit times). The ability of the electroretinogram and other visual function tests to identify eyes at risk to progress to the more severe retinopathy stages will be tested in a longitudinal 5-9 year study of 250 diabetic patients who are part of the Early Treatment Diabetic Retinopathy Study. The EGR parameters, alone and in conjunction with the Farnsworth-Munsell 100 hue test scores and Goldmann visual field scores at baseline will be related to the subsequent development of proliferative diabetic retinopathy. If these tests prove to have predictive value, they can be used in the future to select patients with high risk characteristics in order to institute earlier or more vigorous medical or surgical therapeutic intervention.