REFRACTIVE KERATOPLASTY: A LABORATORY INVESTIGATION

屈光性角膜移植术是一种手术， 为了矫正眼睛的屈光不正而弯曲。 手术范围可以从在皮肤上产生精确的手术切口， 角膜到车床切割的异体或人基质的植入 小姑娘 本申请旨在调查 异体，特别是水凝胶，角膜内晶状体（ICL）， 屈光性角膜移植术 水凝胶材料目前用于 含水量高（50 - 80%）的长戴型隐形眼镜， 对溶质渗透性很强。 由于这些特性，沿着 具有精确车削给定功率和基弧的能力， 对水凝胶的非反应性组织反应， 材料，它是作为ICL的绝佳选择。 然而，这是一个外国 物质的身体，永远不会被整合到组织作为人类 可能是供体角膜。 从生物学角度来说人类捐献角膜是 作为植入材料，但是更难以精确地车床切割， 提供了不太可靠的材料供应， 稳定的小行星 水凝胶ICLS的有效性将通过长期的 术语非人灵长类临床和形态学研究，以定义 程序的可预测性和稳定性。 的光学分析 将进行数据分析以帮助预测手术结果。 的 ICL对角膜生理学如瘢痕形成，肿胀， 压力、基质弹性、耗氧量等，将被评估。 水凝胶材料的物理特性，即，渗透性， 药物吸收和释放、弹性等，将被定义。 的 这项工作将在人类临床试验之前确定水凝胶ICL的疗效。 审判

Refractive keratoplasty is a surgical procedure to alter the cornea's curvature for the purpose of correcting the refractive error of the eye. The procedure can range from producing precise surgical incisions in the cornea to implantation of either a lathe cut alloplastic or human stroma lenticule. This application is directed toward an investigation in the use of alloplastic, specifically hydrogel, intracorneal lenses (ICLs) for refractive keratoplasty. Hydrogel materials are presently being used for extended wear contact lenses that are high (50-80%) in water content and are very permeable to solutes. Because of these characteristics, along with the ability to precisely lathe cut a given power and base curve, the non-reactive tissue response to hydrogels, stability and availability of material, it is an excellent choice as an ICL. Yet, it is a foreign substance to the body and will never be integrated into the tissue as human donor cornea may be. Human donor cornea is biologically the perfect choice as an implant material, but is more difficult to precisely lathe cut, offers a less reliable supply of material and possibly a less dimensionally stable lenticule. The efficacy of hydrogel ICLS will be evaluated by long term non-human primate clinical and morphological studies to define the predictibility and stability of the procedure. An optical analysis of the data will be performed to aid in predicting the surgical outcome. The effect of the ICL on corneal physiology such as scarring, swelling, pressure, stromal elasticity, oxygen consumption, etc., will be assessed. The physical characteristics of the hydrogel material, i.e., permeability, drug uptake and release, elastic properties, etc., will be defined. The work will establish the efficacy of hydrogel ICLs prior to human clinical trials.