ACCOMODATION IN AMBLYOPIA

本提案的目的是定量研究 早期异常的视觉体验，导致弱视，对人类 调节系统，主要强调目标对比度和空间 频率分量贡献 功能性弱视受试者 将是主要目标人群;匹配的对照将包括 视觉正常的个体以及无弱视的斜视。 四 将进行以下几组实验：（1）监测住宿情况 连续和客观地使用红外视力计，和平均 将使用计算机平均值确定缓解响应水平 程序，无论是弱视或同胞优势眼的意见和重点 在各种对比度（80至接近0%）/空间的正弦光栅上 频率（0.5、4.0或16.0周/度）组合;（2） 将使用一个 红外视力计，平均屈光反应水平将是 使用计算机平均程序确定，因为弱视或 另一只主眼观看并聚焦于高对比度方波 光栅、具有相同基波的高对比度正弦波光栅 频率，或基本正弦波光栅与添加 越来越高阶（第三、第五和第七）的奇次谐波正弦 （3）对比辨别将被调查，使用 强迫选择设计和统计技术，通过让受试者 判断闪烁的正弦测试光栅的对比度是否相同， 或不同于闪烁的正弦参考光栅;辨别 将测试几种对比度/空间频率组合， 在弱视矫正治疗过程中，使用 上述实验1 - 3中描述的刺激和方法。

The objective of this proposal is to investigate quantitatively the effects of early abnormal visual experience, leading to amblyopia, on the human accommodation system, with primary emphasis on target contrast and spatial frequency component contributions. Subjects having functional amblyopia will be the primary target population; matched controls will include visually-normal individuals as well as strabismics without amblyopia. Four sets of experiments will be conducted: (1) accommodation will be monitored continuously and objectively using an infrared optometer, and the average accommodative response level will be determined using a computer averaging program, as either the amblyopic or fellow dominant eye views and focuses on a sinusoidal grating at a variety of contrast (80 to nearly 0%)/spatial frequency (0.5, 4.0, or 16.0 cycles per deg.) combinations; (2) accommodation will be monitored continuously and objectively using an infrared optometer, and the average accommodative response level will be determined using a computer averaging program, as either the amblyopic or fellow dominant eye views and focuses on either a high contrast square-wave grating, a high contrast sine-wave grating having the same fundamental frequency, or the fundamental sine-wave grating with addition of increasingly higher-order (3rd, 5th, and 7th), odd harmonic sinusoidal components; (3) contrast discrimination will be investigated, using a forced-choice design and statistical techniques, by having the subject judge whether the contrast of a flashed sinusoidal test grating is the same or different than a flashed sinusiodal reference grating; discrimination will be tested for sevral contrast/spatial frequency combination will be followed during the course of orthoptic therapy for the amblyopia, using the stimuli and methods described in experiments 1 - 3 above.