Exploring novel binding pockets in DNA gyrase and DNA topoisomerase IV to address antibiotic resistance

探索 DNA 旋转酶和 DNA 拓扑异构酶 IV 中的新型结合袋以解决抗生素耐药性问题

• 批准号: BB/V007041/1
• 负责人: Colin Fishwick
• 金额: $ 57.76万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FV007041%2F1
• 关键词: Exploring; novel; binding; pockets; DNA

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前GtR中并没有所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但也可能是因为摘要中包含个人详细信息等敏感信息。

项目成果

De Novo Design of Type II Topoisomerase Inhibitors as Potential Antimicrobial Agents Targeting a Novel Binding Region

作为针对新型结合区域的潜在抗菌剂的 II 型拓扑异构酶抑制剂的从头设计

• DOI: 10.33774/chemrxiv-2021-290nh
• 发表时间: 2021
• 作者: Orritt K

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV.

• DOI: 10.3390/ph16020261
• 发表时间: 2023-02-08
• 期刊: PHARMACEUTICALS
• 影响因子: 4.6
• 作者: Grossman, Scott;Fishwick, Colin W. G.;McPhillie, Martin J.
• 通讯作者: McPhillie, Martin J.

De novo design of type II topoisomerase inhibitors as potential antimicrobial agents targeting a novel binding region.

• DOI: 10.1039/d2md00049k
• 发表时间: 2022-07-20
• 期刊: RSC medicinal chemistry
• 影响因子: 4.1