GENETIC CONTROL OF MAMMALIAN DIFFERENTIATION

这个研究项目涉及哺乳动物的 发育遗传学 它特别关注的是 鉴定特定的基因，包括结构基因和调节基因， 控制着胚胎发育和细胞生长的各个方面 形态发生和生化水平的分化。 小鼠中影响发育和分化的突变 作为这些研究的工具。 基因识别 造成的特定发育缺陷提供了潜在的 阐明相应的正常发育机制 以及它们的基因控制 特别注意的是， 小鼠致死性白化病缺失复合体。 这些似乎 包括与控制特异性相关的调节基因 肝细胞分化的过程。 遗传学方法，发育 生物学，生物化学，体细胞遗传学，电子显微镜， 细胞学和分子生物学为这些研究服务。 研究 这里提出的模型系统提供了研究出生 人类新陈代谢的缺陷和先天性缺陷。 它开辟了 先天性畸形病因学的新观点， 强调了具有类似疾病的遗传异质性， 外观，例如糖原累积病和其他代谢性疾病 异常

This research project deals with problems of mammalian developmental genetics. In particular it is concerned with the identification of specific genes, both structural and regulatory, which control various aspects of embryonic development and cell differentiation on levels of morphogenesis and biochemistry. Mutations in the mouse affecting development and differentiation serve as tools in these studies. The identification of genetically caused specific developmental defects provides the potential of elucidating the corresponding normal mechanisms of development and their genetic control. Particular attention centers on a complex of lethal albino deletion in the mouse. These appear to include regulatory genes concerned specifically with the control of liver cell differentiation. Methods of genetics, developmental biology, biochemistry, somatic cell genetics, electronmicroscopy, cytology and molecular biology serve these studies. The research proposed here provides model systems for the study of birth defects and inborn errors of metabolism in humans. It opens up new views on the etiology of congenital malformations and underscores the genetic heterogeneity of conditions with similar appearances, e.g. glycogen storage diseases and other metabolic abnormalities.