课题基金 / 基金详情

PARALYSIS-ITS ANTAGONISM DURING SURGERY AND ANESTHESIA

PARALYSIS-ITS ANTAGONISM DURING SURGERY AND ANESTHESIA
麻痹——手术和麻醉期间的拮抗作用
批准号：
3273882
负责人：
RONALD D MILLER
金额：
$15.67万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1979
资助国家：
美国
项目状态：
已结题
起止时间：
1979-04-01 至 1985-11-30
来源：
https://reporter.nih.gov/project-details/3273882
关键词：
anesthesia drug adverse effect drug metabolism human old age (65+) human subject liver disorder mathematical model neostigmine neuromuscular blocking agents paralysis pharmacokinetics pyridostigmine renal failure surgery tubocurarine

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英文摘要
A mathematical pharmacokinetic and pharmacodynamic model was initially developed which can be used in the clinical operating room setting without interfering with routine clinical care. We determined the pharmacokinetics and pharmacodynamics of commonly used neuromuscular blocking drugs (d-tubocurarine and pancruonium) and common antagonists of a non-depolarizing neuromuscular blockade (neostigmine and pyridostigmine). In order to complete these studies a suitable assay to measure drug concentration in body fluids had to be developed. We implemented an immunoassay technique for measuring d-tubocurarine; a high performance liquid chromatography method was developed for measuring neostigmine and pyridostigmine in body fluids. Most recently, a mass spectrometry method was developed for measuring pancuronium concentrations in body fluids. We then determined the influence of renal failure, hepatic disease and hypothermia on the pharmacokinetics and pharmacodynamics of the drugs listed above.
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SURGERY, ANESTHESIOLOGY & TRAUMA STUDY SECTION
  • 批准号：
    3555154
  • 项目类别：
  • 资助金额：
    $7.0万
  • 财政年份：
    1988
  • 负责人：
    RONALD D MILLER
  • 依托单位：
    U.S. PHS PUBLIC ADVISORY GROUPS
SURGERY, ANESTHESIOLOGY & TRAUMA STUDY SECTION
  • 批准号：
    3555153
  • 项目类别：
  • 资助金额：
    $0.07万
  • 财政年份：
    1988
  • 负责人：
    RONALD D MILLER
  • 依托单位：
    U.S. PHS PUBLIC ADVISORY GROUPS
SURGERY, ANESTHESIOLOGY & TRAUMA STUDY SECTION
  • 批准号：
    3555160
  • 项目类别：
  • 资助金额：
    $6.0万
  • 财政年份：
    1988
  • 负责人：
    RONALD D MILLER
  • 依托单位：
    U.S. PHS PUBLIC ADVISORY GROUPS
SURGERY, ANESTHESIOLOGY & TRAUMA STUDY SECTION
  • 批准号：
    3555152
  • 项目类别：
  • 资助金额：
    $10.0万
  • 财政年份：
    1988
  • 负责人：
    RONALD D MILLER
  • 依托单位：
    U.S. PHS PUBLIC ADVISORY GROUPS