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ACTIVE OXYGEN GENERATION BY HEPATIC MICROSOMES

ACTIVE OXYGEN GENERATION BY HEPATIC MICROSOMES
肝微粒体产生活性氧
批准号：
3273994
负责人：
JOHN B SCHENKMAN
金额：
$13.08万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
1978
资助国家：
美国
项目状态：
已结题
起止时间：
1978-08-01 至 1987-08-31
来源：
https://reporter.nih.gov/project-details/3273994
关键词：
NAD(H) phosphate antibody specificity centrifugation drug metabolism epinephrine fatty acids gas chromatography liver metabolism mass spectrometry microsomes oxygen consumption peroxidases pyrimidine nucleotides respiratory oxygen stoichiometry

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中文摘要
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英文摘要
We propose that the cytochrome P-450 mixed function oxidase reaction contains two reactions, one an NADPH oxidase and the other a monooxygenase reaction. To date attempts to study stoichiometries of the monooxygenase reaction have been confused by the generation of H2O2, a component of the NADPH-oxidase. We have developed a mechanism which envelopes both reactions and will attempt to show that during the mixed function oxidase reaction, uncoupling of active oxygen with subsequent discharge of oxygenated cytochrome P-450, yields H2O2. Influence of different substrates on the stoichiometries will be examined.
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