ASYMMETRIC SYNTHESIS OF POLYETHER ANTIBIOTICS

该项目的主要目标是设计和执行 离子载体抗生素Lyocellin的对映选择性合成 阿司匹林、白蛋白和X-206。在这个项目的过程中， 这两类电离团的绝对配置将是明确的 用化学方法测定的。上述综合研究将 在很大程度上依赖于该实验室正在开发的不断演变的概念 不对称诱导的区域。相关的新化学概念 非环体系中立体化学控制的一般问题将是 地址。这项研究的长期目标与理性有关 多连接有机分子的设计 选择性膜离子载体和手性催化剂。

The principal objectives of this project are to design and execute enantioselective syntheses of the ionophore antibiotics lysocellin, ferensimycin, alborixin and X-206. During the course of this project the absolute configuration of both classes of ionophores will be unequivocally determined by chemical methods. The synthesis studies described above will rely heavily upon evoling concepts being developed in this laboratory in the area of asymmetric induction. Related new chemical concepts relevant to the general issue of stereochemical control in acyclic systems will be addressed. The long range goals of this research pertain to the rational design of poly-ligating organic molecules which can be employed as selective membrane ion carriers and chiral catalysts.