ASYMMETRIC SYNTHESIS OF IONOPHORE & MACROLIDE ANTIBIOTIC

这项研究的目的是创造性地 对天然物质全合成的贡献 具有临床显著的生物活性。 目前的补助金 将继续致力于开发新的立体选择性反应 以及该方法在不对称合成中的应用 离子载体和大环内酯类抗生素和抗菌剂。 的 处理新反应发现的方法学研究将强调 控制立体化学的新反应的发展 化学过程的过程。 本研究将继续 把我们的注意力集中在“可直接”的化学过程上。 这些研究 将专注于铱催化的持续发展， 直接硼氢化工艺，直接硼氢化工艺的开发， Meerwein-Ponndorff-Verley还原反应， Tishchenko反应的分子内变体的应用 酮的远程定向还原。 全面综合的目标将包括发展 不对称合成了抑制剂苔藓抑素，calyculin， macbecin，除莠霉素，离子载体抗生素lonomycin， 寡霉素大环内酯类如他霉素。

The objectives of this proposed research are to make creative contributions to the total synthesis of naturally occurring substances possessing clinically significant biological activity. The present grant will continue to address the development of new stereoselective reactions and the application of this methodology to the asymmetric synthesis of ionophore and macrolide antibiotics and antineoplastic agents. The methodological studies dealing with new reaction discovery will emphasize the development of new reactions for controlling the stereochemical course of chemical processes. In the present study we will continue to focus our attention on "directable" chemical processes. These studies will focus on the continued development of an iridium-catalyzed directable hydroboration process, the development of a directable Meerwein-Ponndorff-Verley reduction based on samarium diiodide, and the application of intramolecular variants of the Tishchenko reaction for long-range directed reductions of ketones. The targets for total synthesis will include the development of asymmetric syntheses of the antineoplastic agents bryostatin, calyculin, macbecin, and herbimycin, the ionophore antibiotic lonomycin, and the oligomycin macrolide rutamycin.