SYNTHETIC RECEPTORS AND FUNCTIONAL GROUP ARRAYS

合成受体和功能基团阵列

• 批准号: 3286555
• 负责人: CRAIG S WILCOX
• 金额: $ 15.25万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-06-01 至 1994-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3286555
• 关键词: chemical association; chemical binding; chemical synthesis; molecular biology; nuclear magnetic resonance spectroscopy; organic chemicals; physical chemical interaction; receptor binding; stereoisomer; ultraviolet spectrometry; water solution

A number of new and quite unique organic molecules will be prepared and evaluated. The goal of this work is to define some of the principles and general guidelines necessary to prepare synthetic microenvironments which may control organic chemical reactions. The approaches rely on synthetic methods and procedures created in this lab specifically for preparing organized functional group arrays and concave molecules. Two new systems test the catalytic potential of pre-organized functional group arrays. Another system is designed to evaluate the effects of stress, strain, or distortion on substrate reactivity. In another part of the project, additional binding sites will be attached to successful water soluble hosts in order to enhance the selectivity of these hosts. Specificity of binding is required if a microenvironment is to selectively bind a reactive intermediate or transition state of a reaction. A new molecular system which binds to itself and to trans-decalin is to be further developed. Good alkane binding sites may lead to useful methods of selective alkane functionalization.

许多新的和非常独特的有机分子将被制备出来