SYNTHESIS AND PHOTOCHEMISTRY OF SUBSTITUTED PORPHYRINS

取代卟啉的合成及光化学

基本信息

  • 批准号:
    3289793
  • 负责人:
  • 金额:
    $ 10.02万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1986
  • 资助国家:
    美国
  • 起止时间:
    1986-12-01 至 1989-11-30
  • 项目状态:
    已结题

项目摘要

Our long-term objectives are to develop synthetic methods for creating bioorganic molecules which can be used to provide insight into the relation between molecular structure and biological function. We have developed a room temperature biomimetic synthesis of tetraphenyl-porphyrin in 60% yield. We will expand the scope of this methodology to prepare porphyrins which have previously been unobtainable. This includes the class of meso-alkylporphyrins, some of which should be extremely soluble in lipid media. Amphipathic porphyrins can then be prepared for bilayer studies. Then we will exploit this new methodology in the high yield synthesis of cofacial dimers containing porphyrins and chlorins. We plan an extensive study of the electronic interactions resulting from the juxtaposition of rings. To model the light harvesting apparatus of photosynthesis, we will design and synthesize porphyrins bearing bulky substituents which in the crystalline state will hold the porphyrins at fixed distances apart. Fluorescence measurements in applied electric fields should provide data to distinguish the mechanisms of energy transfer. These new synthetic porphyrins should be of considerable value in extending our understanding of the properties of heme and chlorophyll in biological systems. A more global problem in bioorganic chemistry is the synthesis of model systems having well-defined 3-dimensional structures. We propose to create modular model systems of the photosynthetic process which contain a donor and acceptor covalently linked in a stacked geometry. The spacer groups separating the donor and acceptor are composed of p-aminobenzoic subunits, which are coupled together in a stepwise manner analogous to peptide and DNA synthesis. Three porphyrin-quinone compounds of 5, 10, and 15 A separation will be prepared which have 1, 2, and 3 subunits in their spacer groups. The photochemical characterization of this family of molecules will provide a systematic study of the effect of distances on electron transfer reactions. This modular approach should have broad applicability in the bioorganic field.
我们的长期目标是开发创造的综合方法

项目成果

期刊论文数量(0)
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JONATHAN SIDNEY LINDSEY其他文献

JONATHAN SIDNEY LINDSEY的其他文献

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{{ truncateString('JONATHAN SIDNEY LINDSEY', 18)}}的其他基金

Stable cationic bacteriochlorins for antimicrobial photodynamic therapy
用于抗菌光动力治疗的稳定阳离子菌绿素
  • 批准号:
    7218167
  • 财政年份:
    2007
  • 资助金额:
    $ 10.02万
  • 项目类别:
Stable cationic bacteriochlorins for antimicrobial photodynamic therapy
用于抗菌光动力治疗的稳定阳离子菌绿素
  • 批准号:
    7429748
  • 财政年份:
    2007
  • 资助金额:
    $ 10.02万
  • 项目类别:
PORPHYRIN SYNTHETIC METHODS FOR BIOORGANIC APPLICATIONS
用于生物有机应用的卟啉合成方法
  • 批准号:
    6329668
  • 财政年份:
    1986
  • 资助金额:
    $ 10.02万
  • 项目类别:
PORPHYRIN SYNTHETIC METHODS FOR BIOORGANIC APPLICATIONS
用于生物有机应用的卟啉合成方法
  • 批准号:
    2734539
  • 财政年份:
    1986
  • 资助金额:
    $ 10.02万
  • 项目类别:
PORPHYRIN SYNTHETIC METHODS FOR BIOORGANIC APPLICATIONS
用于生物有机应用的卟啉合成方法
  • 批准号:
    2178232
  • 财政年份:
    1986
  • 资助金额:
    $ 10.02万
  • 项目类别:
PORPHYRIN SYNTHETIC METHODS FOR BIOORGANIC APPLICATIONS
用于生物有机应用的卟啉合成方法
  • 批准号:
    2178231
  • 财政年份:
    1986
  • 资助金额:
    $ 10.02万
  • 项目类别:
SYNTHESIS AND PHOTOCHEMISTRY OF SUBSTITUTED PORPHYRINS
取代卟啉的合成及光化学
  • 批准号:
    3289790
  • 财政年份:
    1986
  • 资助金额:
    $ 10.02万
  • 项目类别:
Porphyrin Synthetic Methods for Bioorganic Applications
用于生物有机应用的卟啉合成方法
  • 批准号:
    6824682
  • 财政年份:
    1986
  • 资助金额:
    $ 10.02万
  • 项目类别:
Porphyrin Synthetic Methods for Bioorganic Applications
用于生物有机应用的卟啉合成方法
  • 批准号:
    6830197
  • 财政年份:
    1986
  • 资助金额:
    $ 10.02万
  • 项目类别:
PORPHYRIN SYNTHETIC METHODS FOR BIOORGANIC APPLICATIONS
用于生物有机应用的卟啉合成方法
  • 批准号:
    6476466
  • 财政年份:
    1986
  • 资助金额:
    $ 10.02万
  • 项目类别:

相似海外基金

SPP 1136: Chemical Substitution in Ionic Solids
SPP 1136:离子固体中的化学取代
  • 批准号:
    5471621
  • 财政年份:
    2002
  • 资助金额:
    $ 10.02万
  • 项目类别:
    Priority Programmes
Chemical Substitution in Glucosides and Their Derivatives
糖苷及其衍生物的化学取代
  • 批准号:
    6215645
  • 财政年份:
    1962
  • 资助金额:
    $ 10.02万
  • 项目类别:
Chemical Substitution in Glucosides and Their Derivatives;
糖苷及其衍生物的化学取代;
  • 批准号:
    5904769
  • 财政年份:
    1959
  • 资助金额:
    $ 10.02万
  • 项目类别:
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