Novel Microbial Pd Catalysts from Waste for Sustainable Synthesis

钯(Pd)是现代化工和制药行业广泛使用的催化剂，由于全球需求增加和供应链压力，钯(Pd)供不应求。我们最近的研究表明，阿拉斯加脱硫弧菌可以从废物中回收钯，作为纳米催化剂重复使用，这种催化剂可以在节能的生产条件下工作。从细菌中提取的钯催化剂具有增强的化学性质，可以催化制药工业中使用的小分子的形成。在这里，我们将(I)优化纳米颗粒以用于这种催化；(Ii)设计重复使用和再制造的路线，以便钯可以连续回收和再利用；(Iii)扩大由细菌衍生的钯催化的反应组合，并展示其他金属纳米颗粒的催化作用。这一新兴的生物技术为Pd的可持续使用铺平了道路，为改进Pd催化剂创造了新的循环途径，并取代了目前的Pd催化剂使用的线性模式，这种模式产生了浪费，是不可持续的，并且依赖于不安全的供应链。

Palladium (Pd) is a widely used catalyst in the modern chemical and pharmaceutical industries and is in short supply due to increasing global demand and supply chain pressures. Our recent studies have shown that the bacterium Desulfovibrio alaskensis can be used to recover Pd from waste for reuse as nanoparticle catalysts which work under energy-efficient manufacturing conditions. The Pd catalysts derived from the bacteria display enhanced chemical properties and can catalyze the formation of small molecules of use in the pharmaceutical industry. Here, we will (i) optimise the nanoparticles for this catalysis (ii) devise routes for their reuse and remanufacture so that the Pd can be continuously recovered and reused and (iii) expand the portfolio of reactions catalysed by the bacterially derived Pd and demonstrate catalysis with other metal nanoparticles. This emerging biotechnology paves the way for the sustainable use of Pd, creating new circular pathways to improved Pd catalysts and replacing the current linear model of Pd catalyst use, which creates waste, is unsustainable and reliant on insecure supply chains.