NMR-BASE: Nuclear Magnetic Resonance for Biomolecule Analysis in Supported Environments

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The biggest challenge in the invention of new biomedicines and biomaterials is understanding how they function at a molecular level in the context for which they are designed to work. While it is possible and necessary to examine such materials in isolation, their true purpose is revealed in their real living contexts or mimics of these. To bridge the gap that exists at the level of how designed medicines work, the NMR-BASE facility will be established to help users "see" the behaviour of their molecules in complex matrices, those that are significant in the context of therapeutic purpose. NMR-BASE will be established for the UK scientific community by providing researchers with access to state-of-the-art equipment to examine the fine details of molecular structure and behaviour in ways which will help the molecule design process to progress. The equipment will be suitable for the widest range of sample types and will be capable of supporting live cells as well as providing access to the study of tissues, gels and other "soft" materials that form the basis of many biological materials and systems. The equipment will enable a variety of scientific approaches to be used for studying molecules in their true contexts and will benefit the design process for new medicines and biomaterials. It will provide new training opportunities for a wide UK user base including PhD students both locally and nationally, providing access to unique equipment for their research along with the staff to support them. The equipment will be housed within the NMR Facility at the University of Strathclyde, a world-leading technological university which has the skills and expertise required to host and run NMR-BASE optimally.