NMR-BASE: Nuclear Magnetic Resonance for Biomolecule Analysis in Supported Environments

NMR-BASE：在支持的环境中进行生物分子分析的核磁共振

• 批准号: BB/X019594/1
• 负责人: John Parkinson
• 金额: $ 145.02万
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FX019594%2F1
• 关键词: NMR; BASE; Nuclear; Magnetic; Resonance

The biggest challenge in the invention of new biomedicines and biomaterials is understanding how they function at a molecular level in the context for which they are designed to work. While it is possible and necessary to examine such materials in isolation, their true purpose is revealed in their real living contexts or mimics of these. To bridge the gap that exists at the level of how designed medicines work, the NMR-BASE facility will be established to help users "see" the behaviour of their molecules in complex matrices, those that are significant in the context of therapeutic purpose. NMR-BASE will be established for the UK scientific community by providing researchers with access to state-of-the-art equipment to examine the fine details of molecular structure and behaviour in ways which will help the molecule design process to progress. The equipment will be suitable for the widest range of sample types and will be capable of supporting live cells as well as providing access to the study of tissues, gels and other "soft" materials that form the basis of many biological materials and systems. The equipment will enable a variety of scientific approaches to be used for studying molecules in their true contexts and will benefit the design process for new medicines and biomaterials. It will provide new training opportunities for a wide UK user base including PhD students both locally and nationally, providing access to unique equipment for their research along with the staff to support them. The equipment will be housed within the NMR Facility at the University of Strathclyde, a world-leading technological university which has the skills and expertise required to host and run NMR-BASE optimally.

在发明新的生物医药和生物材料的过程中，最大的挑战是理解它们在分子水平上是如何在它们被设计用来工作的环境中起作用的。虽然孤立地研究这些材料是可能的，也是必要的，但它们的真正目的是在它们的真实生活环境或模拟环境中揭示出来的。为了弥合在设计药物如何工作水平上存在的差距，将建立核磁共振基础设施，以帮助用户“看到”他们的分子在复杂基质中的行为，这些分子在治疗目的的背景下具有重要意义。核磁共振基地将为英国科学界建立，为研究人员提供最先进的设备，以检查分子结构和行为的细节，从而帮助分子设计过程取得进展。该设备将适用于最广泛的样品类型，并能够支持活细胞，以及提供组织，凝胶和其他“软”材料的研究，这些材料构成了许多生物材料和系统的基础。该设备将使各种科学方法能够用于研究分子的真实情况，并将有利于新药和生物材料的设计过程。它将为包括本地和全国博士生在内的广泛的英国用户群提供新的培训机会，为他们的研究提供独特的设备以及支持他们的工作人员。该设备将被安置在斯特拉斯克莱德大学的核磁共振设施内，这是一所世界领先的科技大学，拥有最佳托管和运行核磁共振基地所需的技能和专业知识。