PLANE FACTS ON THE MODE OF ACTION OF BICYCLOMYCIN

双环素(1)是一种临床有用的抗生素。收集到的信息 来自正在进行的研究提供了我们当前概念的基础 关于1的作用方式。不幸的是，人们对此知之甚少 关于药物激活过程，关键步骤的能量学，以及 抗生素与受体部位的相互作用(S)。在这 一种关于双环素作用方式的新假说 已经很先进了。已经概述了一种综合的方法，以便进一步 了解药物和受体部位如何发挥作用。详细 还建议进行实验，以辨别由 生物介质在药物活化和结合过程中的作用。知识 这一普遍性质有望提供分子基础 在这一领域的后续研究，并允许未来的一般药物设计 在经验较少的基础上继续进行。

Bicyclomycin (1) is a clinically useful antibiotic. Information gleaned from ongoing studies have provided the basis of our current notions concerning the mode of action of 1. Unfortunately, little is known concerning the drug activation process, the energetics of key steps, and the interaction of the antibiotic with the receptor site(s). In this proposal, a novel hypothesis for the mode of action of bicyclomycin has been advanced. An integrated approach has been outlined for the further understanding of how the drug and the receptor site function. Detailed experiments are also proposed to discern the effects provided by the biological medium in the drug activation and binding process. Knowledge of this general nature is expected to provide the molecular basis for subsequent research in this area, and allow future general drug design to proceed on a less empirical basis.