REGULATION OF CELLULAR PROLIFERATION

本项目的长期目标是了解 参与调节协调基因表达的机制 细胞增殖 白细胞介素2刺激的T淋巴细胞 将被用作研究细胞周期进程的模型。 具体地说，细胞周期蛋白的表达，一种与细胞增殖相关的蛋白， 基因，在初始IL-2刺激的G1活化，活性前， “回向”是回向，回向是回向。 负责调节细胞周期蛋白表达的因子。 此外，本发明还提供了一种方法， 其他细胞周期依赖性基因， 将分离细胞周期蛋白。 分子细胞学技术将是 用于进行这些研究。 的理解 调节正常细胞生长所需的基因 扩散应该能让我们深入了解 肿瘤形成

The long-term objective for this project is to understand the mechanisms involved in regulating coordinate gene expression during cellular proliferation. Interleukin 2 stimulated T lymphocytes will be used as a model to study cell cycle progression. Specifically, the expression of cyclin, a proliferation associated gene, during initial IL2-stimulated G1 activation, active pro- liferation, and return to quiescence will be determined as will the factors responsible for regulating cyclin expression. In addition, other cell cycle dependent genes that regulated coordinately with cyclin will be isolated. Molecular cytological techniques will be used to carry out these studies. An understanding of the regulation of genes that are required for normal cellular proliferation should give us valuable insight into the pathobiology of neoplasia.