APPLICATIONS OF INTRAMOLECULAR ALLYLSILANE CYCLIZATIONS

烯丙基硅烷分子内环化的应用

• 批准号: 3296915
• 负责人: GEORGE F MAJETICH
• 金额: $ 8.09万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1991-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3296915
• 关键词: allyl compound; carboxylation; cyclic compound; drug design /synthesis /production; paclitaxel; silanes

This proposal focuses on the application of allylsilane cyclizations to form medium-sized rings. Novel and expendient syntheses of confertin and neolemnane exploit advantages unique to this annulation strategy. In addition, new methodology has been proposed to further develop this annulation procedure. The cyclization of substrates possessing several Michael acceptors, or internal nucleophiles, is a powerful extension of our earlier studies. Several pilot studies directed toward the ring skeletons of gascardic acid, gibberellic acid, quadrone, ophiobolin A, taxol, dendrobine, and securinine have been presented to expand the scope of our ring-forming processes. The area of allylsilane carbocyclizations remains largely unexplored and has significant potential. Pursuit of the experiments proposed here will further demonstrate the capabilities of this annulation methodology.

本文主要研究烯丙基硅烷环化反应的应用 形成中等大小的环。 新颖且廉价的合成 confertin和neolemnane利用了这一独特的优势， 环化战略 此外，新方法已 建议进一步发展这种环化程序。 的 具有几个迈克尔受体的底物的环化，或 内部亲核试剂，是我们早期的 问题研究 几项针对星环骨架的初步研究 gascardic acid，赤霉酸，quadrone，蛇孢菌素A，紫杉醇， 石斛碱和一叶秋碱已被提出来扩大 我们的成环工艺范围。 烯丙基硅烷碳环化反应的领域仍然很大 未经开发，具有巨大的潜力。 追求 这里提出的实验将进一步证明 这种方法的能力。