PHOSPHOINOSITIDE & INOSITOL PHOSPHATE ANALOG SYNTHESIS

磷酸肌醇

• 批准号: 3297969
• 负责人: ROBERT ENGEL
• 金额: $ 13.54万
• 依托单位: QUEENS COLLEGE
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-12-01 至 1991-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3297969
• 关键词: aminophosphonate; calcium metabolism; chemical cleavage; chemical synthesis; hormone regulation /control mechanism; membrane structure; methylene chloride; phosphatidylinositols; phosphoric ester; phosphorylation

The phosphoinositides and inositol phosphates have been intensively investigated in recent years regarding their role for intracellular signalling in response to extracellular stimuli and providing calcium release. The mechanisms which have been postulated for this activity involve cleavage of phosphate ester linkages of the phosphoinositides and inositol phosphates. In the present work it is postulated that isosteric methylene and hydroxymethylene phosphonic acid analogues of these phosphates be synthesized as probes of the metabolic processes and as potential regulators of the signalling process. The phosphonic acids, unable to undergo the normal hydrolytic procedures, yet maintaining the same size and shape of the natural materials, are anticipated to be able to participate in some of the normal metabolic processes, but to perturb the signalling process which requires phosphate ester cleavage.

磷酸肌醇和肌醇磷酸盐已被广泛研究， 近年来研究了它们在细胞内的作用 响应细胞外刺激的信号传导和提供钙 release. 为这种活动所假定的机制 涉及磷酸肌醇的磷酸酯键的裂解， 肌醇磷酸盐。 在目前的工作中，它是假定， 这些的亚甲基和羟基亚甲基膦酸类似物 合成磷酸盐作为代谢过程的探针， 信号传导过程的潜在调节剂。 膦酸， 不能进行正常的水解程序，但保持 同样大小和形状的天然材料，预计能够 参与一些正常的代谢过程，但要扰乱 需要磷酸酯裂解的信号传导过程。