How protein and RNA cargo are sorted into exosomes

该项目旨在了解蛋白质和RNA是如何被选择包装到外泌体中并参与这些囊泡介导的生物学功能的。外泌体是由细胞释放的小的膜状细胞外囊泡，其含有蛋白质和RNA货物并参与细胞间通讯。确定外泌体货物如何被选择并与其在细胞间通讯中的功能相关，预计将显示这些囊泡如何维持细胞内稳态。这些发现将扩大microRNA生物学，蛋白质组学领域的知识，并发展生物信息学方面的专业知识。

This project aims to understand how proteins and RNA are selected for packaging into exosomes and participate in the biological functions mediated by these vesicles. Exosomes are small membranous extracellular vesicles released by cells which contain protein and RNA cargo and are involved in intercellular communication. Determining how the exosome cargo is selected and related to its function in intercellular communication is expected to show how these vesicles maintain cellular homeostasis. The findings will expand knowledge in the area of microRNA biology, proteomics and develop expertise in bioinformatics.