ANDROGENS AND ANDROGEN RECEPTORS IN MALE INFERTILITY

睾丸间质细胞产生的睾酮， 促黄体生成素刺激垂体分泌， 被认为是生殖细胞发育的重要调节因子。 我们提出 探讨睾丸雄激素异常或 雄激素受体与某些人的生精小管功能障碍有关， 男性不育症的形式。 睾丸类固醇分泌将通过重复性腺静脉研究 精索静脉曲张相关不育男性的抽样调查及结果 与促性腺激素分泌有关。 存在于细胞中的雄激素 用放射免疫分析法研究人睾丸曲细精管 高效液相色谱法分离。 雄激素受体将在人类生精小管中进行研究， 食蟹猴 最后，支持细胞富集培养物来源于 将建立青春期前次人灵长类动物的睾丸， 将探索雄激素代谢和受体结合。 因为特发性男性不育是一种常见的疾病， 有效的治疗，这些研究对临床医生和 生理学，内分泌学，生物化学， 泌尿科和妇科。

Testosterone produced by Leydig cells within the testis, in response to stimulation by Luteinizing Hormone secretion by the pituitary gland, is believed to be an important regulator of germ cell development. We propose to explore the hypothesis that abnormalities of testicular androgens or androgen receptors are related to seminiferous tubule dysfunction in some forms of male infertility. Testicular steroid secretion will be studied by repetitive gonadal vein sampling to men with varicocele-related infertility and the findings related to gonadotropin secretion. The androgens present in the seminiferous tubules of human testis will be studied by radioimmunoassay methods following separation by high performance liquid chromatography. Androgen receptors will be studied in seminiferous tubules from humans and cynomolgus monkeys. Finally, Sertoli cell-enriched cultures derived from the testes of prepubertal subhuman primates will be established and androgen metabolism and receptor binding will be explored. Because idiopathic male infertility is a common disorder with no uniformly effective treatment, these studies are of importance to clinicians and investigators in the fields of physiology, endocrinology, biochemistry, urology, and gynecology.