FETAL LYMPH FLOW

在整个胎儿时期，液体和蛋白质的变化异常迅速 身体及其分布在许多疾病中都是异常的，在许多疾病中， 胎儿和新生儿。淋巴系统在液体中起着至关重要的作用 分配，因为它返回已过滤的液体和蛋白质 从血液回流到循环中。然而，监管机制 胎儿淋巴流量在很大程度上仍不清楚。因此，我们提出以下几点建议 为了更好地理解生理学的这一方面而进行的研究。我们 将研究全身淋巴流动对以下情况的反应：1)连续输注 等渗盐水；2)低渗、等渗和高渗盐水；3) 输注酸性和碱性溶液，以测试pH值的影响；4) 不同电解液和胶体的输注，以测试其效果 单个物质；5)通过出血和改变血容量 卷加载。实验将在精心准备的胎儿中进行 子宫中的羔羊来测试机制。它们将在课程中重复 长期准备的胎儿羔羊、新生儿和成人，以检查 淋巴流量的生理学意义和用来测量变化 成熟。阻断淋巴流动的效果也将被做以测试其 对身体不同器官的重要性。这些实验将会 建立第一个系统研究胎儿淋巴流动并将其排出 阐明淋巴系统在保护身体抵抗疾病方面的重要性 浮肿。

Shifts of fluids and proteins are exceptionally rapid throughout the fetal body and their distribution is abnormal in many diseases with edema in the fetus and newborn. The lymph system plays a critical role in fluid distribution because it returns fluids and proteins that have been filtered from the blood back into the circulation. Yet the mechanisms regulating fetal lymph flow remain largely unknown. We therefore propose several lines of investiagation to better understand this aspect of physiology. We will study whole body lymph flow responses to: 1) successive infusions of isotonic saline; 2) infusions of hypo-, iso-, and hypertonic saline; 3) infusions of acidic and alkaline solutions, to test pH influence; 4) infusions of different electrolytes and colloids to test the effects of individual substances; and 5) changing blood volume by hemorrhage and volume loading. Experiments will be carried out in acutely prepared fetal lambs in utero to test for mechanisms. They will be repeated in chronically prepared fetal lambs, newborns, and adults to examine the physiologic importance of lymph flow and to measure changes with maturation. Effects of blocking lymph flow will also be done to test its importance to different organs of the body. The experiments will constitute the first systematic study of fetal lymph flow and will shed light on the importance of the lymph system in defending the body against edema.