课题基金 / 基金详情

MOLECULAR BASIS OF NORMAL AND MUTANT LIMB DEVELOPMENT

MOLECULAR BASIS OF NORMAL AND MUTANT LIMB DEVELOPMENT
正常和突变肢体发育的分子基础
批准号：
3321241
负责人：
PAUL F GOETINCK
金额：
$25.3万
依托单位：
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
1986
资助国家：
美国
项目状态：
已结题
起止时间：
1986-01-01 至 1991-10-31
来源：
https://reporter.nih.gov/project-details/3321241
关键词：
cartilage development cartilage disorder cartilage metabolism cell differentiation chick embryo chondrocytes collagen congenital skeletal disorder developmental genetics embryo /fetus extracellular matrix gene expression genetic regulatory element histogenesis hyaluronate laboratory mouse laboratory rabbit limbs mesoderm molecular cloning monoclonal antibody nucleic acid probes nucleic acid sequence posttranslational modifications protein sequence protein structure function proteoglycan site directed mutagenesis tissue /cell culture

项目摘要

项目成果

PAUL F GOETINCK的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
The overall goal of the research is to understand the developmental processes that take place in Chip embryonic limb. In this developmental system, changes occur in the activity of a number of genes at the time of differentiation of limb mesodermal cells into chondrocytes. We will study: a) the structure-function relationship of the translation products of newly activated genes in the establishment of the cartilaginous matrix, b) the regulatory sequences that are specific for the expression of one of these genes in chondrocytes and c) the morphogenetic consequences of induced and spontaneous mutations that affect cartilage matrix macromolecules.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
SYNDECAN-4 SIGNALING IN CELL-MATRIX INTERACTIONS
  • 批准号：
    6521167
  • 项目类别：
  • 资助金额：
    $32.67万
  • 财政年份：
    1999
  • 负责人：
    PAUL F GOETINCK
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
Syndecan-4 signaling in cell-matrix interactions
  • 批准号：
    6877793
  • 项目类别：
  • 资助金额：
    $36.07万
  • 财政年份：
    1999
  • 负责人：
    PAUL F GOETINCK
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
SYNDECAN-4 SIGNALING IN CELL-MATRIX INTERACTIONS
  • 批准号：
    6636983
  • 项目类别：
  • 资助金额：
    $33.54万
  • 财政年份：
    1999
  • 负责人：
    PAUL F GOETINCK
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
Syndecan-4 signaling in cell-matrix interactions
海外基金