PRENATAL EXPOSURE TO BARBITURATES & BEHAVIORAL EFFECTS

产前接触巴比妥类药物

• 批准号: 3319703
• 负责人: BARBARA J VAN DEN BERG
• 金额: $ 8.54万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-12-01 至 1986-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3319703
• 关键词: adolescence (12-20); barbiturates; child (0-11); child behavior; child mental disorders; cognition; drug adverse effect; menstrual cycle disorder; middle childhood (6-11); postnatal growth disorder; prenatal stress; preschool child (1-5)

We plan to use the extensive data of the Child Health and Development Studies, covering the prenatal episode as well as the children's health and development until adolescence, to test hypotheses regarding long-term effects of prenatal barbituate exposure. A large body of published studies, mainly based on experiments with rodents, emphasizes changes in behavior of maturing and adult animals as a result of prenatal or perinatal exposure to barbiturates. Few long-term studies on humans have been done, notwithstanding a rather frequent use of barbiturates, also during pregnancy. The data sets of CHDS are particularly well suited for evaluations of long-term effects as our data include completely coded information on pharmaceuticals, linked to the diseases or conditions for which these drugs were prescribed. Developmental examinations of 5 year olds, 10 year olds and adolescents provide information on cognitive development and on behavioral characteristics. This information will be used to evaluate associations between prenatal barbiturate exposure and later behavioral characteristics.

我们计划利用儿童健康和发展的广泛数据 研究，涵盖产前插曲以及儿童健康和 发展到青春期，以检验关于长期的假设 出生前接触巴比妥酸盐的影响。 大量已发表的研究，主要基于 啮齿动物，强调成熟和成年动物行为的变化 产前或围产期暴露于巴比妥酸盐的结果。很少有长期的 对人类的研究已经完成，尽管相当频繁地使用 巴比妥酸盐，也是在怀孕期间。 CHDS的数据集特别适合于评估 长期影响，因为我们的数据包括完全编码的信息 药物，与这些药物所针对的疾病或情况有关 都是处方药。5岁、10岁儿童的发育检查 青少年提供关于认知发展和其他方面的信息 行为特征。此信息将用于评估 产前暴露巴比妥酸盐与后期行为的关系 特点。