PRENATAL EXPOSURE TO BARBITURATES & BEHAVIORAL EFFECTS

我们计划利用儿童健康和发展的广泛数据， 研究，包括产前事件以及儿童的健康， 发展到青春期，以测试关于长期的假设 产前暴露的影响。 大量已发表的研究，主要基于以下实验： 啮齿类动物，强调成熟和成年动物的行为变化， 产前或围产期暴露于巴比妥酸盐的结果。 很少长期 尽管人类经常使用 巴比土酸盐，也在怀孕期间。 CHDS的数据集特别适合于评估 长期影响，因为我们的数据包括完全编码的信息 药物，与这些药物所治疗的疾病或病症有关 是开处方的 5奥尔兹、10岁儿童的发育检查 和青少年提供有关认知发展和 行为特征 这些信息将用于评估 产前巴比妥酸盐暴露与日后行为的关系 特色

We plan to use the extensive data of the Child Health and Development Studies, covering the prenatal episode as well as the children's health and development until adolescence, to test hypotheses regarding long-term effects of prenatal barbituate exposure. A large body of published studies, mainly based on experiments with rodents, emphasizes changes in behavior of maturing and adult animals as a result of prenatal or perinatal exposure to barbiturates. Few long-term studies on humans have been done, notwithstanding a rather frequent use of barbiturates, also during pregnancy. The data sets of CHDS are particularly well suited for evaluations of long-term effects as our data include completely coded information on pharmaceuticals, linked to the diseases or conditions for which these drugs were prescribed. Developmental examinations of 5 year olds, 10 year olds and adolescents provide information on cognitive development and on behavioral characteristics. This information will be used to evaluate associations between prenatal barbiturate exposure and later behavioral characteristics.