MYOCARDIAL AND CORONARY EFFECTS OF CARDIAC SYMPATHECTOMY

主要目标是：1)进一步检验心肌梗死的假说 外表面和内表面之间的代谢活动是不平衡的 左心功能正常，2)确定对心脏的影响 交感神经对心肌代谢活动及代谢的影响 和侧支血流对冠状动脉闭塞的反应，以及3)澄清 左心肌血流量及其分布的物理决定因素 脑室。评价局部心肌代谢活动的个体 碳-14标记的代谢物将通过冠脉插管给药 狗和动物将在不同或最佳的时间被牺牲以进行比较 在组织代谢产物和二氧化碳中掺入碳-14 脑室的不同层面。为了评估心脏神经支配的作用， 局部应用苯酚将用于产生区域交感神经切除 去神经和神经支配区域的左心室和代谢状况 将会被比较。为了评估心肌血流量的物理决定因素， 狗的主要左冠状动脉将被插管，从数据来看 不同冠脉压力对冠脉流量、冠脉闭合的影响 压力将在不同的脑室充盈状态下进行测定和比较 压力和冠状动脉静脉压。过河流量高峰时间的研究 不同时间、不同时间的冠脉闭塞的解除 将进行冠脉阻断前压力评估粘弹性。 冠状动脉的行为。

The primary objectives are: 1) to test further the hypothesis that myocardial metabolic activity is uneven between the outer and inner surfaces of the normally functioning left ventricle, 2) to determine the influence of cardiac sympathetic innervation on myocardial metabolic activity, and on the metabolic and collateral blood flow responses to coronary occlusion, and 3) to clarify the physical determinants of myocardial blood flow and its distribution in the left ventricle. To assess regional myocardial metabolic activity individual carbon-14 labeled metabolites will be administered via a coronary cannula to dogs and the animals will be sacrificed at different or optimal times to compare incorporation of carbon-14 into tissue metabolites and carbon dioxide in different layers of the ventricle. To assess the role of cardiac innervation, topically applied phenol will be used to produce a regional sympathectomy of the left ventricle and metabolic conditions in the denervated and innervated regions will be compared. To assess the physical determinants of myocardial blood flow, the main left coronary artery of the dog will be cannulated and, from data on the effects of varying coronary pressure on coronary flow, the coronary closing pressure will be determined and compared at various ventricular filling pressures and coronary venous pressures. Studies on the time to peak flow after release of coronary occlusions of different durations and with different preocclusion coronary pressures will be performed to assess the viscoelastic behavior of the coronary vessels.