METABOLIC PREDICTORS AND MARKERS OF CHILDHOOD OBESITY

这个国家日益普遍的肥胖症引起了公众的严重关注。 相关疾病和并发症对健康的影响。尽管 越来越多的证据表明肥胖是一种先天性遗传性疾病 胰岛素刺激的燃料代谢异常，几乎没有什么是 已知早期代谢缺陷的性质和前驱因素 儿童肥胖相关并发症是成人肥胖的高危人群。 在本研究中，我们将通过执行以下操作来检验这些问题 瘦肉型和肥胖型的代谢和临床综合评估 父母均受异常影响的青春期前儿童 肥胖。正血糖、高胰岛素钳夹技术将用于 稳定同位素示踪剂输注与间接量热法相结合 识别胰岛素刺激的血糖、氨基酸和血脂的缺陷 新陈代谢。高血糖钳夹将被用来检测血管的变化 葡萄糖刺激的胰岛素反应。高危儿童的结果 将与非肥胖父母的苗条青春期前儿童进行比较， 通常对胰岛素非常敏感的受试者，以及患有 对葡萄糖的胰岛素反应最低。高危人群中的代谢缺陷 人口将与脂肪分布的变化有关，由 核磁共振技术。每一组都将被前瞻性地跟踪到青春期。 为了确定新陈代谢异常的演变以及如何 它们与体内脂肪的积累和分布有关，而 血压和循环血脂变化的发展。在……里面 综上所述，这些研究将为机制提供新的重要数据 这是人类肥胖发展的根本原因。

The increasing prevalence of obesity in this country has grave public health implications due to associated diseases and complications. Despite increasing evidence that obesity is a genetic disorder with inherent abnormalities in insulin-stimulated fuel metabolism, virtually nothing is known about the nature of early metabolic defects and the antecedents of obesity-related complications in children at high risk for adult obesity. In the present study, we will examine these questions by performing comprehensive metabolic and clinical assessments in lean and obese preadolescent children of parents who are both affected with abnormal obesity. The euglycemic, hyperinsulinemic clamp technique will be used in combination with stable isotopic tracer infusions and indirect calorimetry to identify defects in insulin-stimulated glucose, amino acid and lipid metabolism. The hyperglycemic clamp will be used to detect alterations in glucose-stimulated insulin responses. Results in the high risk children will be compared with those in lean preadolescents of nonobese parents, subjects who are normally exquisitely sensitive to insulin and who have the lowest insulin responses to glucose. Metabolic defects in the at risk population will be related to alterations in fat distribution assessed by MRI techniques. Each group will be prospectively followed into adolescence in order to determine the evolution of the metabolic abnormalities and how they are related to accumulation and distribution of body fat and the development of changes in blood pressure and circulating lipids. In summary, these studies will provide new important data on the mechanisms underlying the development of obesity in humans.