METABOLIC PREDICTORS AND MARKERS OF CHILDHOOD OBESITY

肥胖症在这个国家日益流行， 由于相关疾病和并发症对健康的影响。 尽管 越来越多的证据表明，肥胖是一种遗传性疾病， 胰岛素刺激的燃料代谢异常，实际上没有什么是 了解早期代谢缺陷的性质和 成人肥胖高危儿童的肥胖相关并发症。 在本研究中，我们将通过以下方式来研究这些问题： 对瘦型和肥胖型患者进行全面的代谢和临床评估 青春期前的孩子的父母都受到异常 肥胖 正常血糖、高胰岛素钳夹技术将用于 结合稳定同位素示踪剂注入和间接量热法 确定胰岛素刺激的葡萄糖、氨基酸和脂质的缺陷 新陈代谢. 高血糖钳夹将用于检测 葡萄糖刺激的胰岛素反应。 结果高危儿童 将与非肥胖父母的消瘦青春期前儿童进行比较， 正常情况下对胰岛素非常敏感的受试者 胰岛素对葡萄糖的反应最低。 代谢缺陷的风险 人群将与脂肪分布的改变相关， MRI技术。 每一组都将被前瞻性地跟踪到青春期 为了确定代谢异常的演变以及如何 它们与体内脂肪的积累和分布有关， 血压和循环脂质发生变化。 在 总之，这些研究将提供新的重要数据的机制， 导致人类肥胖的根本原因

The increasing prevalence of obesity in this country has grave public health implications due to associated diseases and complications. Despite increasing evidence that obesity is a genetic disorder with inherent abnormalities in insulin-stimulated fuel metabolism, virtually nothing is known about the nature of early metabolic defects and the antecedents of obesity-related complications in children at high risk for adult obesity. In the present study, we will examine these questions by performing comprehensive metabolic and clinical assessments in lean and obese preadolescent children of parents who are both affected with abnormal obesity. The euglycemic, hyperinsulinemic clamp technique will be used in combination with stable isotopic tracer infusions and indirect calorimetry to identify defects in insulin-stimulated glucose, amino acid and lipid metabolism. The hyperglycemic clamp will be used to detect alterations in glucose-stimulated insulin responses. Results in the high risk children will be compared with those in lean preadolescents of nonobese parents, subjects who are normally exquisitely sensitive to insulin and who have the lowest insulin responses to glucose. Metabolic defects in the at risk population will be related to alterations in fat distribution assessed by MRI techniques. Each group will be prospectively followed into adolescence in order to determine the evolution of the metabolic abnormalities and how they are related to accumulation and distribution of body fat and the development of changes in blood pressure and circulating lipids. In summary, these studies will provide new important data on the mechanisms underlying the development of obesity in humans.