Surface Engineered Biomaterials to Control Inflammation

控制炎症的表面工程生物材料

• 批准号: DP150104212
• 负责人: Prof Krasimir Vasilev
• 金额: $ 22.72万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-29 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150104212
• 关键词: Surface; Engineered; Biomaterials; Control; Inflammation

The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Experimental evidence demonstrates that engineered surface nanotopography in combination with surface chemistry downregulates the expression of proinflammatory cytokines from primary macrophages. The significance of these findings is that it may be possible to engineer the nanotopography of a biomedical device surface in a manner which leads to a desired and predictable level of inflammation and subsequent foreign body reaction (FBR) medical implants and tissue engineering constructs.

这个项目的首要目标是提供一个表面纳米形貌如何影响炎症反应的机制的理解。实验证据表明，工程表面纳米形貌与表面化学相结合，下调了原代巨噬细胞的促炎细胞因子的表达。这些发现的重要性在于，可以以导致期望的和可预测的炎症水平以及随后的异物反应（FBR）医疗植入物和组织工程构造的方式来设计生物医学装置表面的纳米形貌。