BIOSYNTHESIS AND DEGRADATION OF BLOOD GROUP SUBSTANCES

膜结构在细胞的形态和功能中起着重要的作用。 细胞的分化。 糖缀合物的碳水化合物部分， 糖蛋白和糖脂，经常被发现是负责 这些生物学特性。 因此，简单的碳水化合物残基可以 影响组织的完整性、肿瘤的转移、细胞的归巢 在胚胎发育和其他细胞相互作用中，例如 哺乳动物细胞和细菌或病毒。 因此，可以得出结论， 糖复合物的行为就像“识别位点”。“我们最近 证明了这种识别位点在以下方面也发挥着重要作用： 血液学，例如唾液酸在红细胞活力中的作用 在流通。 因此，我们的目标是确定机制， 并鉴定所涉及的糖缀合物。 他们似乎是 糖复合物的血型类型。 为此，我们打算破解 碳水化合物代码通过使用我们实验室开发的技术，如 β-消除还原裂解方法和所述方法的用途 α-N-乙酰半乳糖胺寡糖酶和其他糖苷酶。 得出的结论将通过可行性研究得到证实， 使用大鼠、小鼠、兔和/或狗。

Membrane structures play an important role in the morphology and differentiation of cells. The carbohydrate moiety of glycoconjugates, glycoproteins and glycolipids, have frequently been found to be responsible for these biological properties. Thus, simple carbohydrate residues can affect the integrity of tissues, metastasis of tumors, the homing of cells in embryological development and other cellular interactions, e.g. between mammalian cells and bacteria or viruses. It might be concluded, therefore, that glycoconjugates behave as "Recognition Sites." We have recently demonstrated that such Recognition Sites play an important role also in hematology, e.g. the role of sialic acid in the viability of erythrocytes in circulation. Our objective, therefore, is to ascertain the mechanism, and to identify the glycoconjugate(s) involved. They appear to be of the blood group types of glycoconjugates. To that end we intend to crack the carbohydrate code by using techniques developed in our lab such as the Beta-elimination reductive cleavage procedure and the use of the Alpha-N-acetylgalactosaminyl -oligosaccharidase and other glycosidases. The conclusions arrived at will be confirmed by viability studies involving the use of rats, mice, rabbits and/or dogs.