NEUROGENIC CONTROL OF THE CIRCULATION

结论：这些研究旨在澄清 调节脑血流量和通过主动脉血管的流量。 今年的具体目标是：1）确定是否切断交感神经 神经对脑血管产生中风的高血压大鼠; 2）， 确定是否刺激或阻断胆碱能途径， 脑血管改变脑血流的调节; 3）确定 颅内压升高是否会引起脑血管再分布 血液流动以及交感神经是否对这种效应有贡献。 今年最重要的成就是， 在慢性高血压患者中，去神经支配易患中风， 重要的一步，在澄清的生理作用，神经控制， 大脑循环。 这一观察结果可能对医生很重要 为高血压患者提供护理和预防中风。 明年的研究目标是回答这些问题：1） 交感神经刺激引起脑节段性电阻变化 通过收缩大动脉但扩张小血管来抵抗血管？ 2)交感神经通路的生理激活是否影响脑血 流动？ 3)岩浅大神经是 脑血管的胆碱能神经支配

OBJECTIVES: These studies are directed at clarification of factors that regulate cerebral blood flow and flow through aortic vasa vasorum. Specific goals this year were 1) to determine whether cutting sympathetic nerves to cerebral vessels produces stroke in hypertensive rats; 2) to determine whether stimulation or interruption of cholinergic pathways to cerebral vessels alters regulation of cerebral blood flow; 3) to determine whether increases in intracranial pressure produce redistribution of cerebral blood flow and whether sympathetic nerves contribute to this effect. The most significant achievement this year was the finding that sympathetic denervation predisposes to stroke in the presence of chronic hypertension is an important step in clarification of the physiological role of neural control in the cerebral circulation. This observation may be of importance to physicians who provide care to patients with hypertension and in prevention of stroke. Research goals for the coming year are to answer these questions: 1) Does sympathetic stimulation produce a shift in segmental resistance of cerebral resistance vessels by constricting large arteries but dilating small vessels? 2) Does physiological activation of sympathetic pathways affect cerebral blood flow? 3) Is the greater superficial petrosal nerve the primary source of cholinergic innervation of cerebral vessels?