NEUROGENIC CONTROL OF THE CIRCULATION

循环的神经源性控制

• 批准号: 3335126
• 负责人: DONALD D HEISTAD
• 金额: $ 14.64万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-12-01 至 1986-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3335126
• 关键词: afferent nerve; atropine; bradykinin; brain circulation; cardiovascular pharmacology; chemoreceptors; choline acetyltransferase; dopamine; human subject; hypercapnia; hypoxia; intracranial pressure; neurogenic hypertension; nitroglycerin; norepinephrine; sympathetic nervous system; vasodilators

OBJECTIVES: These studies are directed at clarification of factors that regulate cerebral blood flow and flow through aortic vasa vasorum. Specific goals this year were 1) to determine whether cutting sympathetic nerves to cerebral vessels produces stroke in hypertensive rats; 2) to determine whether stimulation or interruption of cholinergic pathways to cerebral vessels alters regulation of cerebral blood flow; 3) to determine whether increases in intracranial pressure produce redistribution of cerebral blood flow and whether sympathetic nerves contribute to this effect. The most significant achievement this year was the finding that sympathetic denervation predisposes to stroke in the presence of chronic hypertension is an important step in clarification of the physiological role of neural control in the cerebral circulation. This observation may be of importance to physicians who provide care to patients with hypertension and in prevention of stroke. Research goals for the coming year are to answer these questions: 1) Does sympathetic stimulation produce a shift in segmental resistance of cerebral resistance vessels by constricting large arteries but dilating small vessels? 2) Does physiological activation of sympathetic pathways affect cerebral blood flow? 3) Is the greater superficial petrosal nerve the primary source of cholinergic innervation of cerebral vessels?

目的：这些研究旨在澄清影响因素 调节脑血流量和通过主动脉血管滋养管的流量。 今年的具体目标是 1) 确定是否切割同情心 脑血管神经导致高血压大鼠中风； 2）到 确定是否刺激或中断胆碱能通路 脑血管改变脑血流的调节； 3）确定 颅内压增高是否会导致大脑的重新分布 血流量以及交感神经是否有助于这种效果。 今年最重要的成就是发现同情 去神经支配在慢性高血压的情况下容易发生中风 阐明神经控制的生理作用的重要一步 脑循环。 这一观察结果对医生可能很重要 他们为高血压患者提供护理并预防中风。 来年的研究目标是回答以下问题：1） 交感神经刺激引起大脑节段电阻的变化 通过收缩大动脉但扩张小血管来抵抗血管？ 2）交感神经通路的生理激活是否影响脑血 流动？ 3) 岩大浅神经是主要来源吗 脑血管的胆碱能神经支配？