REGULATION OF SKIN BLOOD FLOW IN MAN

人体皮肤血流的调节伴随着反射和 地方机制。 神经控制不仅源于体温调节 反射，但也来自非温度调节反射，如那些 与运动和血压调节有关。 地方机制 包括与局部皮肤水平相关的重要成分 血流测量部位的温度。 这个项目是一个 继续探索这一区域的监管， 当这些控制源相互竞争时， 其他或一致行动。 重点将继续放在 在运动过程中调节皮肤血液流动，其中有一个 体温调节和非体温调节之间的内在竞争 反射 本建议中涉及的具体问题包括：（a） 皮肤血流量或出汗率对运动反应更多地取决于 强烈地对参与锻炼的肌肉质量，特定的肌肉 组，或运动模式（等距与动态）？ (b)是 皮肤血管系统对以下疾病的发生和持续的反应： 动态运动还是等长运动取决于运动水平？ (c)可以 最大皮肤血流量被定义？ (d)动脉闭塞是否 腕部静脉闭塞法体积描记术用腕部静脉闭塞法代替 闭塞？ (e)皮肤血管收缩剂对血管收缩剂的反应 人的潜水反射被局部或全身减弱或消除 体温过高？ (f)用激光多普勒测量皮肤血流 充分遵循体积描记测量时，皮肤 血管收缩？ 这些问题的答案将大大扩展我们的知识 关于控制这种流通，并应设置阶段， 了解这种控制在疾病状态下是如何改变的， 提供评估热应激影响和风险的依据， 心血管疾病患者的运动。

Regulation of skin blood flow in man is accompanied by both reflex and local mechanisms. Neural control derives not only from thermoregulatory reflexes, but also from non-thermoregulatory reflexes, such as those associated with exercise and blood pressure regulation. Local mechanisms include an important component associated with the level of local skin temperature at the site of blood flow measurement. This project is a continuation of our exploration into the regulation of this regional circulation when these sources of control are in competition with each other or are acting in concert. Major emphasis will continue to be placed on the regulation of skin blood flow during exercise, in which there is a built-in competition between thermoregulatory and non-thermoregulatory reflexes. Specific questions addressed in this proposal include (a) does the response of skin blood flow or of sweat rate to exercise depend more strongly on the muscle mass involved in the exercise, the specific muscle group, or on the mode of exercise (isometric versus dynamic)? (b) is the response of the cutaneous vasculature to the onset and continuation of dynamic or isometric exercise dependent on the level of exercise? (c) can a maximal skin blood flow be defined? (d) can the arterial occlusion at the wrist in venous occlusion plethysmography be replaced by wrist venous occlusion? (e) can the potent cutaneous vasoconstrictor response to the diving reflex in man be attenuated or abolished by local or whole body hyperthermia? (f) Do laser-doppler measurements of skin blood flow adequately follow plethysmographic measurements when the skin is vasoconstricted? Answers to these questions will substantially extend our knowledge regarding the control of this circulation and should set the stage for understanding how such control is modified in disease states as well as offer a rationale by which to assess the impact and risk of heat stress and exercise of patients with cardiovascular disease.